One-stage Penile Urethroplasty Using Oral Mucosal Graft and Glue

Guido Barbagli, Graziella Pellegrini, Francesca Corradini, Francesco Montorsi, Salvatore Sansalone, Denis Butnaru, Massimo Lazzeri

Research output: Contribution to journalArticlepeer-review


Background Repair of penile urethral strictures is a challenging problem for which different techniques have been suggested. Objective To describe a new surgical technique for one-stage penile urethroplasty using an oral graft and glue, and to assess its safety and efficacy. Design, setting, and participants A retrospective review of medical records for patients who underwent one-stage penile urethroplasty using oral mucosa and glue from February 2013 to October 2014 was performed. Surgical procedure The penile urethra was opened and the urethral plate was incised to create a wide window within which the oral graft was pasted with glue. The urethra was sutured over the catheter. Outcome measurements and statistical analysis Clinical data were collected in a database. Intraoperative and postoperative complications and outcomes were assessed. A descriptive statistical analysis was performed. Results and limitations Fourteen patients were included in the study. Median operative time was 60 min. The median postoperative stay was 3 d. Three intraoperative and one postoperative complication occurred. In all patients, voiding cystourethrography 2 wk after surgery failed to show urethral fistula or sacculation. No patients complained of penile chordee or sexual dysfunction after surgery. Median follow-up was 16 mo. Among the 14 patients, 12 (85.7%) procedures were successful and two (14.3%) were failures. Study limitations include the small sample size and short follow-up. Conclusions An in vitro study and a one-stage reconstruction of penile urethral strictures with an oral mucosa graft and glue showed that the procedure is safe and efficient, but further studies including larger series of patients and longer follow-up are required. Patient summary We report on the repair of penile urethral stricture using one-stage urethroplasty with oral mucosa and glue. This new technique was safe and effective, with limited complications and satisfactory outcomes. We plan to increase the use of this technique in the future.
Original languageEnglish
Pages (from-to)1069 - 1075
Number of pages7
JournalEuropean Urology
Issue number6
Publication statusPublished - Dec 1 2016


  • Glue
  • One-stage urethroplasty
  • Oral mucosal graft
  • Penile stricture

ASJC Scopus subject areas

  • Urology


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