One-step arthroscopic technique for the treatment of osteochondral lesions of the knee with bone-marrow-derived cells: Three years results

Roberto Buda, Francesca Vannini, Marco Cavallo, Matteo Baldassarri, Deianira Luciani, Antonio Mazzotti, Camilla Pungetti, Alessandra Olivieri, Sandro Giannini

Research output: Contribution to journalArticle

38 Citations (Scopus)

Abstract

Osteochondral lesions of the knee (OLK) are a common cause of knee pain and associated diseases. A new bone-marrow-derived mesenchymal stem cells technique has been developed for the treatment of OLK. 30 patients with OLK underwent arthroscopic one-step procedure. The bone marrow was harvested from the patients' posterior iliac crest and arthroscopically implanted with a scaffold into the lesion site. Clinical inspection and MRI were performed. Mean International Knee Documentation Committee (IKDC) score before surgery was 29.9 ± 13.2 and 85.4 ± 4.2 at 29 ± 4.1 months (p <0.0005), while Knee injury and Osteoarthritis Outcome Score (KOOS) before surgery was 35.1 ± 11.9 and 87.3 ± 7.3 at 29 ± 4.1 months (p <0.0005). Control MRI and bioptic samples showed an osteochondral regeneration of the lesion site. The one-step technique appears to be a good and reliable option for treatment of OLK at three years of follow-up. Level of evidence Case series, Level IV.

Original languageEnglish
Pages (from-to)145-151
Number of pages7
JournalMusculoskeletal Surgery
Volume97
Issue number2
DOIs
Publication statusPublished - Aug 2013

Fingerprint

Bone Marrow Cells
Knee
Therapeutics
Bone Marrow
Knee Injuries
Knee Osteoarthritis
Mesenchymal Stromal Cells
Documentation
Regeneration
Pain

Keywords

  • Arthroscopic
  • Bone marrow
  • Knee
  • Mesenchymal
  • Osteochondral lesion
  • Stem cells

ASJC Scopus subject areas

  • Orthopedics and Sports Medicine
  • Surgery

Cite this

One-step arthroscopic technique for the treatment of osteochondral lesions of the knee with bone-marrow-derived cells : Three years results. / Buda, Roberto; Vannini, Francesca; Cavallo, Marco; Baldassarri, Matteo; Luciani, Deianira; Mazzotti, Antonio; Pungetti, Camilla; Olivieri, Alessandra; Giannini, Sandro.

In: Musculoskeletal Surgery, Vol. 97, No. 2, 08.2013, p. 145-151.

Research output: Contribution to journalArticle

Buda, Roberto ; Vannini, Francesca ; Cavallo, Marco ; Baldassarri, Matteo ; Luciani, Deianira ; Mazzotti, Antonio ; Pungetti, Camilla ; Olivieri, Alessandra ; Giannini, Sandro. / One-step arthroscopic technique for the treatment of osteochondral lesions of the knee with bone-marrow-derived cells : Three years results. In: Musculoskeletal Surgery. 2013 ; Vol. 97, No. 2. pp. 145-151.
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