One-step cartilage repair with bone marrow aspirate concentrated cells and collagen matrix in full-thickness knee cartilage lesions: Results at 2-year follow-up

Alberto Gobbi, Georgios Karnatzikos, Celeste Scotti, Vivek Mahajan, Laura Mazzucco, Brunella Grigolo

Research output: Contribution to journalArticle

119 Citations (Scopus)

Abstract

Objective: The purpose of our study was to determine the effectiveness of cartilage repair utilizing 1-step surgery with bone marrow aspirate concentrate (BMAC) and a collagen I/III matrix (Chondro-Gide, Geistlich, Wolhusen, Switzerland). Materials and Methods: We prospectively followed up for 2 years 15 patients (mean age, 48 years) who were operated for grade IV cartilage lesions of the knee. Six of the patients had multiple chondral lesions; the average size of the lesions was 9.2 cm 2. All patients underwent a mini-arthrotomy and concomitant transplantation with BMAC covered with the collagen matrix. Coexisting pathologies were treated before or during the same surgery. X-rays and MRI were collected preoperatively and at 1 and 2 years' follow-up. Visual analog scale (VAS), International Knee Documentation Committee (IKDC), Knee injury and Osteoarthritis Outcome Score (KOOS), Lysholm, Marx, SF-36 (physical/mental), and Tegner scores were collected preoperatively and at 6, 12, and 24 months' follow-up. Four patients gave their consent for second-look arthroscopy and 3 of them for a concomitant biopsy. Results: Patients showed significant improvement in all scores at final follow-up (P <0.005). Patients presenting single lesions and patients with small lesions showed higher improvement. MRI showed coverage of the lesion with hyaline-like tissue in all patients in accordance with clinical results. Hyaline-like histological findings were also reported for all the specimens analyzed. No adverse reactions or postoperative complications were noted. Conclusion: This study showed that 1-step surgery with BMAC and collagen I/III matrix could be a viable technique in the treatment of grade IV knee chondral lesions.

Original languageEnglish
Pages (from-to)286-299
Number of pages14
JournalCartilage
Volume2
Issue number3
DOIs
Publication statusPublished - Jul 2011

Fingerprint

Cartilage
Collagen
Surgery
Knee
Bone
Repair
Bone Marrow
Magnetic resonance imaging
Biopsy
Pathology
Hyalin
Tissue
X rays
Knee Injuries
Knee Osteoarthritis
Arthroscopy
Bone Marrow Transplantation
Visual Analog Scale
Switzerland
Documentation

Keywords

  • BMAC
  • Cartilage
  • Chondral lesion
  • Chondro-Gide
  • Knee
  • Plateltex act

ASJC Scopus subject areas

  • Immunology and Allergy
  • Biomedical Engineering
  • Physical Therapy, Sports Therapy and Rehabilitation

Cite this

One-step cartilage repair with bone marrow aspirate concentrated cells and collagen matrix in full-thickness knee cartilage lesions : Results at 2-year follow-up. / Gobbi, Alberto; Karnatzikos, Georgios; Scotti, Celeste; Mahajan, Vivek; Mazzucco, Laura; Grigolo, Brunella.

In: Cartilage, Vol. 2, No. 3, 07.2011, p. 286-299.

Research output: Contribution to journalArticle

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