Purpose: The aim of this study is to prospectively evaluate the medium-term effectiveness and regenerative capability of autologous adult mesenchymal stem cells, harvested as bone marrow aspirate concentrate (BMAC), along with a hyaluronan-based scaffold (Hyalofast) in the treatment of ICRS grade 4 chondral lesions of the knee joint, in patients older than 45 years. Methods: A study group of 20 patients with an age >45 years (mean 50.0 ± 4.1 years) was compared to a control group of 20 patients with an age 45 years population with functional outcomes that are comparable to younger patients at final follow-up. Level of evidence: Prospective cohort study, Level II.
- Bone Marrow Aspirate Concentrate (BMAC)
- Cartilage lesion
- Mesenchymal Stem cells (MSCs)
ASJC Scopus subject areas
- Orthopedics and Sports Medicine