One-step surgery with multipotent stem cells and Hyaluronan-based scaffold for the treatment of full-thickness chondral defects of the knee in patients older than 45 years

Alberto Gobbi, Celeste Scotti, Georgios Karnatzikos, Abhishek Mudhigere, Marc Castro, Giuseppe M. Peretti

Research output: Contribution to journalArticlepeer-review

Abstract

Purpose: The aim of this study is to prospectively evaluate the medium-term effectiveness and regenerative capability of autologous adult mesenchymal stem cells, harvested as bone marrow aspirate concentrate (BMAC), along with a hyaluronan-based scaffold (Hyalofast) in the treatment of ICRS grade 4 chondral lesions of the knee joint, in patients older than 45 years. Methods: A study group of 20 patients with an age >45 years (mean 50.0 ± 4.1 years) was compared to a control group of 20 patients with an age 45 years population with functional outcomes that are comparable to younger patients at final follow-up. Level of evidence: Prospective cohort study, Level II.

Original languageEnglish
Pages (from-to)2494-2501
Number of pages8
JournalKnee Surgery, Sports Traumatology, Arthroscopy
Volume25
Issue number8
DOIs
Publication statusPublished - Aug 2017

Keywords

  • Bone Marrow Aspirate Concentrate (BMAC)
  • Cartilage
  • Cartilage lesion
  • Hyaluronan
  • Mesenchymal Stem cells (MSCs)
  • Scaffold

ASJC Scopus subject areas

  • Orthopedics and Sports Medicine
  • Surgery

Fingerprint Dive into the research topics of 'One-step surgery with multipotent stem cells and Hyaluronan-based scaffold for the treatment of full-thickness chondral defects of the knee in patients older than 45 years'. Together they form a unique fingerprint.

Cite this