One-year clinical outcome of biodegradable polymer sirolimus-eluting stent in patients presenting with acute myocardial infarction: Insight from the ULISSE registry: Catheterization and Cardiovascular Interventions

E Moscarella, A Ielasi, A Beneduce, G Ferrante, AC Pivato, M Chiarito, A Cappelletti, G Perfetti, V Magni, E Prati, S Falcone, A Pierri, S De Martini, M Montorfano, R Parisi, D Rutigliano, N Locuratolo, A Anzuini, P Calabrò, M TespiliA Margonato, A Benassi, C Briguori, F Fabbiocchi, B Reimers, A Bartorelli, A Colombo, C Godino

Research output: Contribution to journalArticlepeer-review

Abstract

Background: The ULISSE registry has demonstrated the real-world performance of the Ultimaster biodegradable polymer sirolimus-eluting stent (BP-SES) in a large cohort of patients undergoing percutaneous coronary intervention, including a large proportion of patients presenting with acute myocardial infarction (AMI). Methods: We performed a subgroup analysis of the ULISSE registry in AMI patients and compared the outcomes of this vulnerable cohort with that of patients presenting without AMI (non-AMI). The primary end point was the incidence of 1-year target lesion failure (TLF), a composite of cardiac death, target vessel myocardial infarction (TV-MI), and clinically indicated target lesion revascularization (TLR). Results: Of 1,660 patients included in the ULISSE registry, 381(23%) presented with AMI, 207(54.3%) non-ST elevation myocardial infarction, and 174(45.7%) ST-elevation myocardial infarction. Compared with non-AMI patients, those with AMI were more frequently female and smokers, with lower left ventricular ejection fraction (LVEF) and chronic kidney disease requiring dialysis. At 1 year, TLF rate was significantly higher in AMI than non-AMI patients (7.9 vs. 4.1%; HR 1.98, CI 95% 1.22–3.23; p =.005) driven by higher rate of cardiac death (4.0 vs. 1.1%; HR 3.59, CI 95% 1.64–7.88; p =.01) and TV-MI (2.8 vs 0.9%; HR 2.99,CI 95% 1.22–7.37; p =.01), without differences in TLR rate (4.3 vs. 2.9%,HR 0.66, CI95% 0.35–1.25; p =.2). At multivariate Cox regression analysis, eGFR
Original languageEnglish
Pages (from-to)972-979
Number of pages8
JournalCatheterization and Cardiovascular Interventions
Volume94
Issue number7
DOIs
Publication statusPublished - 2019

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