One year follow-up study of T-cell subsets and incidence of seropositivity for HTLV-I and HTLV-III antibodies in patients treated 'on demand' or sporadically with clotting concentrates

F. Rodeghiero, G. C. Castaman, T. Chisesi, A. De Rossi, O. Dalla Gassa, A. Del Mistro, E. Dini, S. Castronovo, E. Pornaro, L. Chieco-Bianchi

Research output: Contribution to journalArticle

Abstract

A 1-year follow-up study of the T-cell subset abnormalities was carried out in 16 severe haemophilia A patients, treated 'on demand' with an average amount of 500 U/kg/yr of factor VIII concentrate (group A) and in 15 haemophiliacs or von Willebrand patients treated only sporadically with less than 3000 U of factor VIII and no longer exposed to any other blood component in the 2 years preceding the beginning of the study (group B). In group A, 50% and 70% of patients showed a reduced or inverted T 4/T 8 ratio, respectively, at the beginning and at the end of follow-up. These values were of 30% and 20% in patients of group B, suggesting a long-lasting effect of concentrate therapy on T-cell subsets. The low T 4/T 8 ratio was mainly due to an increase of suppressor cells. None of the patients was found positive for anti HTLV-I, whereas 3 patients, all belonging to the group A, showed antibodies against HTLV-III. Thus, in these patients, HTLV-III seems not to be the only cause of lot T 4/T 8 ratio.

Original languageEnglish
Pages (from-to)665-668
Number of pages4
JournalThrombosis and Haemostasis
Volume54
Issue number3
Publication statusPublished - 1985

ASJC Scopus subject areas

  • Hematology

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