One-year mortality in elderly adults with non-st-elevation acute coronary syndrome: Effect of diabetic status and admission hyperglycemia

Stefano Savonitto, Nuccia Morici, Claudio Cavallini, Roberto Antonicelli, Anna Sonia Petronio, Ernesto Murena, Zoran Olivari, Giuseppe Steffenino, Francesco Bonechi, Antonio Mafrici, Anna Toso, Federico Piscione, Leonardo Bolognese, Stefano De Servi

Research output: Contribution to journalArticlepeer-review

Abstract

Objectives To determine whether type 2 diabetes mellitus and hyperglycemia on admission should be considered independent predictors of mortality in elderly adults with acute coronary syndrome (ACS). Design Prospective cohort study. Setting Twenty-three hospitals in Italy. Participants Individuals aged 75 and older with non-ST-elevation ACS (NSTEACS) (mean age 82, 47% female) (N = 645). Measurements Diabetic status and blood glucose levels were assessed on admission. Hyperglycemia was defined as glucose greater than 140 mg/dL. Multivariable Cox proportional hazard regression was used to assess the potential confounding effect of major covariates on the association between diabetic status, admission glucose, and 1-year mortality. Results A history of diabetes mellitus was found in 231 participants (35.8%), whereas 257 (39.8%) had hyperglycemia. Hyperglycemia was found in 171 participants with diabetes mellitus (70%) and 86 (21%) without diabetes mellitus. Participants with diabetes mellitus were significantly (P

Original languageEnglish
Pages (from-to)1297-1303
Number of pages7
JournalJournal of the American Geriatrics Society
Volume62
Issue number7
DOIs
Publication statusPublished - 2014

Keywords

  • acute coronary syndrome
  • diabetes mellitus
  • elderly
  • hyperglycemia
  • mortality

ASJC Scopus subject areas

  • Geriatrics and Gerontology

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