One-year outcome of small-vessel disease treated with sirolimus-eluting stents: A subgroup analysis of the e-select registry

Runlin Gao, Alexandre Abizaid, Adrian Banning, Antonio L. Bartorelli, Vladimír Džavík, Stephen Ellis, Myung Ho Jeong, Victor Legrand, Christian Spaulding, Philip Urban

Research output: Contribution to journalArticlepeer-review


Objectives To investigate the characteristics and one-year outcomes following sirolimus-eluting CYPHER Select Plus stent (SES) implantation in small (SmVD) and non-small vessel disease (NSmVD) in the international e-SELECT registry. Background Large-scale registry data are lacking on DES outcomes in SmVD treatment. Methods There were 4,700 SmVD (at least one vessel with estimated reference vessel diameter [RVD] <2.5 mm, excluding 283 patients with unknown RVD vessels) and 10,139 NSmVD only patients. Results The SmVD population was older, with more women, diabetics, and vessels treated, higher mean Charlson Comorbidity Index score (CCI), shorter lesions, and less STEMI presentation. The 1-year stent thrombosis (ST) rate (primary end-point), was significantly higher (1.3% vs. 0.7%) in SmVD versus NSmVD, mainly driven by early events. One-year major adverse cardiac event (MACE), myocardial infarction (MI), and clinically indicated target-lesion revascularization (TLR) rates were significantly higher in SmVD although death and major bleeding rates were similar in both groups. Complication rates were similar between pure (3,188 patients; only RVD <2.5 mm) and mixed (1,795 patients; some RVD <2.5 mm or unknown RVD) SmVD. Multivariate predictors for 1-year MACE in SmVD included saphenous vein graft or bifurcation lesions, major bleeding, any antiplatelet therapy discontinuation within 1 month, age, number of stents implanted, CCI, acute coronary syndrome, and insulin-dependent diabetes mellitus. Conclusion SES implantation for SmVD occurs more frequently in women, diabetics, and those with multivessel disease and comorbidities. One-year ST, MACE, MI, and clinically indicated TLR rates are higher, although low overall, in SmVD or mixed SmVD patients while death rates are similar to NSmVD. (J Interven Cardiol 2013;26:163-172)

Original languageEnglish
Pages (from-to)163-172
Number of pages10
JournalJournal of Interventional Cardiology
Issue number2
Publication statusPublished - Apr 2013

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Radiology Nuclear Medicine and imaging


Dive into the research topics of 'One-year outcome of small-vessel disease treated with sirolimus-eluting stents: A subgroup analysis of the e-select registry'. Together they form a unique fingerprint.

Cite this