One-year repeated cycles of cognitive training (CT) for Alzheimer's disease

Susanna Bergamaschi, Giorgio Arcara, Attilio Calza, Daniele Villani, Vasiliki Orgeta, Sara Mondini

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Background: Recent research suggests that a combination of both pharmacological and psychosocial treatments targeting cognitive functions improves cognition in patients with Alzheimer's disease (AD). The present study evaluated the effectiveness of a 1-year cognitive training (CT) by comparing the cognitive performance of 16 patients with AD treated with CT and cholinesterase inhibitors (ChEIs) (experimental group) with the performance of 16 patients treated with a non-specific cognitive treatment and ChEIs (control group). Methods: This study was a single-blind randomized controlled trial. The patients in the experimental group received pharmacological treatment and repeated cycles of CT for 1 year, whereas the control group received pharmacological treatment and repeated cycles of non-specific cognitive exercises. The patients in the two groups were administered a variety of neuropsychological tests measuring several cognitive functions (i.e. memory, language, reasoning, executive function, working memory and apraxia), activities of daily living, and depression. Results: After 1 year of training, the experimental group scored significantly higher on the Mini Mental State Examination, the Milan Overall Dementia Assessment battery and in other five neuropsychological tests, compared to the control group. Conclusions: Present results suggest that repeated cycles of CT in patients with AD treated with ChEIs are associated with benefits in several areas of cognitive function.

Original languageEnglish
Pages (from-to)421-426
Number of pages6
JournalAging clinical and experimental research
Volume25
Issue number4
DOIs
Publication statusPublished - Aug 2013

Fingerprint

Alzheimer Disease
Cognition
Cholinesterase Inhibitors
Neuropsychological Tests
Pharmacology
Control Groups
Apraxias
Executive Function
Therapeutics
Activities of Daily Living
Short-Term Memory
Dementia
Language
Randomized Controlled Trials
Exercise
Depression
Research

Keywords

  • Cognitive impairment
  • Dementia
  • Neuropsychological assessment
  • Non-pharmacological interventions

ASJC Scopus subject areas

  • Ageing
  • Geriatrics and Gerontology

Cite this

Bergamaschi, S., Arcara, G., Calza, A., Villani, D., Orgeta, V., & Mondini, S. (2013). One-year repeated cycles of cognitive training (CT) for Alzheimer's disease. Aging clinical and experimental research, 25(4), 421-426. https://doi.org/10.1007/s40520-013-0065-2

One-year repeated cycles of cognitive training (CT) for Alzheimer's disease. / Bergamaschi, Susanna; Arcara, Giorgio; Calza, Attilio; Villani, Daniele; Orgeta, Vasiliki; Mondini, Sara.

In: Aging clinical and experimental research, Vol. 25, No. 4, 08.2013, p. 421-426.

Research output: Contribution to journalArticle

Bergamaschi, S, Arcara, G, Calza, A, Villani, D, Orgeta, V & Mondini, S 2013, 'One-year repeated cycles of cognitive training (CT) for Alzheimer's disease', Aging clinical and experimental research, vol. 25, no. 4, pp. 421-426. https://doi.org/10.1007/s40520-013-0065-2
Bergamaschi, Susanna ; Arcara, Giorgio ; Calza, Attilio ; Villani, Daniele ; Orgeta, Vasiliki ; Mondini, Sara. / One-year repeated cycles of cognitive training (CT) for Alzheimer's disease. In: Aging clinical and experimental research. 2013 ; Vol. 25, No. 4. pp. 421-426.
@article{834378f6a25746258da0d491f03eb9b4,
title = "One-year repeated cycles of cognitive training (CT) for Alzheimer's disease",
abstract = "Background: Recent research suggests that a combination of both pharmacological and psychosocial treatments targeting cognitive functions improves cognition in patients with Alzheimer's disease (AD). The present study evaluated the effectiveness of a 1-year cognitive training (CT) by comparing the cognitive performance of 16 patients with AD treated with CT and cholinesterase inhibitors (ChEIs) (experimental group) with the performance of 16 patients treated with a non-specific cognitive treatment and ChEIs (control group). Methods: This study was a single-blind randomized controlled trial. The patients in the experimental group received pharmacological treatment and repeated cycles of CT for 1 year, whereas the control group received pharmacological treatment and repeated cycles of non-specific cognitive exercises. The patients in the two groups were administered a variety of neuropsychological tests measuring several cognitive functions (i.e. memory, language, reasoning, executive function, working memory and apraxia), activities of daily living, and depression. Results: After 1 year of training, the experimental group scored significantly higher on the Mini Mental State Examination, the Milan Overall Dementia Assessment battery and in other five neuropsychological tests, compared to the control group. Conclusions: Present results suggest that repeated cycles of CT in patients with AD treated with ChEIs are associated with benefits in several areas of cognitive function.",
keywords = "Cognitive impairment, Dementia, Neuropsychological assessment, Non-pharmacological interventions",
author = "Susanna Bergamaschi and Giorgio Arcara and Attilio Calza and Daniele Villani and Vasiliki Orgeta and Sara Mondini",
year = "2013",
month = "8",
doi = "10.1007/s40520-013-0065-2",
language = "English",
volume = "25",
pages = "421--426",
journal = "Aging clinical and experimental research",
issn = "1594-0667",
publisher = "Springer International Publishing AG",
number = "4",

}

TY - JOUR

T1 - One-year repeated cycles of cognitive training (CT) for Alzheimer's disease

AU - Bergamaschi, Susanna

AU - Arcara, Giorgio

AU - Calza, Attilio

AU - Villani, Daniele

AU - Orgeta, Vasiliki

AU - Mondini, Sara

PY - 2013/8

Y1 - 2013/8

N2 - Background: Recent research suggests that a combination of both pharmacological and psychosocial treatments targeting cognitive functions improves cognition in patients with Alzheimer's disease (AD). The present study evaluated the effectiveness of a 1-year cognitive training (CT) by comparing the cognitive performance of 16 patients with AD treated with CT and cholinesterase inhibitors (ChEIs) (experimental group) with the performance of 16 patients treated with a non-specific cognitive treatment and ChEIs (control group). Methods: This study was a single-blind randomized controlled trial. The patients in the experimental group received pharmacological treatment and repeated cycles of CT for 1 year, whereas the control group received pharmacological treatment and repeated cycles of non-specific cognitive exercises. The patients in the two groups were administered a variety of neuropsychological tests measuring several cognitive functions (i.e. memory, language, reasoning, executive function, working memory and apraxia), activities of daily living, and depression. Results: After 1 year of training, the experimental group scored significantly higher on the Mini Mental State Examination, the Milan Overall Dementia Assessment battery and in other five neuropsychological tests, compared to the control group. Conclusions: Present results suggest that repeated cycles of CT in patients with AD treated with ChEIs are associated with benefits in several areas of cognitive function.

AB - Background: Recent research suggests that a combination of both pharmacological and psychosocial treatments targeting cognitive functions improves cognition in patients with Alzheimer's disease (AD). The present study evaluated the effectiveness of a 1-year cognitive training (CT) by comparing the cognitive performance of 16 patients with AD treated with CT and cholinesterase inhibitors (ChEIs) (experimental group) with the performance of 16 patients treated with a non-specific cognitive treatment and ChEIs (control group). Methods: This study was a single-blind randomized controlled trial. The patients in the experimental group received pharmacological treatment and repeated cycles of CT for 1 year, whereas the control group received pharmacological treatment and repeated cycles of non-specific cognitive exercises. The patients in the two groups were administered a variety of neuropsychological tests measuring several cognitive functions (i.e. memory, language, reasoning, executive function, working memory and apraxia), activities of daily living, and depression. Results: After 1 year of training, the experimental group scored significantly higher on the Mini Mental State Examination, the Milan Overall Dementia Assessment battery and in other five neuropsychological tests, compared to the control group. Conclusions: Present results suggest that repeated cycles of CT in patients with AD treated with ChEIs are associated with benefits in several areas of cognitive function.

KW - Cognitive impairment

KW - Dementia

KW - Neuropsychological assessment

KW - Non-pharmacological interventions

UR - http://www.scopus.com/inward/record.url?scp=84886648326&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84886648326&partnerID=8YFLogxK

U2 - 10.1007/s40520-013-0065-2

DO - 10.1007/s40520-013-0065-2

M3 - Article

VL - 25

SP - 421

EP - 426

JO - Aging clinical and experimental research

JF - Aging clinical and experimental research

SN - 1594-0667

IS - 4

ER -