One-year treatment with liraglutide improved renal function in patients with type 2 diabetes: a pilot prospective study

Marco Zavattaro; Marina Caputo; Maria Teresa Samà; Chiara Mele; Luisa Chasseur; Paolo Marzullo; Loredana Pagano; Maria Grazia Mauri; Maria Chantal Ponziani; Gianluca Aimaretti; Flavia Prodam

doi:10.1007/s12020-014-0519-0

One-year treatment with liraglutide improved renal function in patients with type 2 diabetes: a pilot prospective study

Marco Zavattaro, Marina Caputo, Maria Teresa Samà, Chiara Mele, Luisa Chasseur, Paolo Marzullo, Loredana Pagano, Maria Grazia Mauri, Maria Chantal Ponziani, Gianluca Aimaretti, Flavia Prodam

Fondazione Istituto Auxologico Italiano

Research output: Contribution to journal › Article › peer-review

Abstract

Unlike GLP-1, liraglutide is not cleared by the glomerulus and its pharmacokinetic is not altered in patients with mild renal impairment. The aim of our study was to analyze the effects of liraglutide on renal function in patients with type 2 diabetes. A twelve-month longitudinal prospective post-marketing study was performed. According to eGFR (estimated glomerular filtration rate) calculated with CKD-EPI equation, 84 consecutive patients were divided in Group A (eGFR > 90 ml/min) and Group B (eGFR 1c (p 90 ml/min). At baseline, five patients had pathological microalbuminuria, but at 12 months three of them returned to normal albuminuria (p

Original language	English
Pages (from-to)	620-626
Number of pages	7
Journal	Endocrine
Volume	50
Issue number	3
DOIs	https://doi.org/10.1007/s12020-014-0519-0
Publication status	Published - Dec 1 2015

Keywords

Diabetes
Human
Kidney
Liraglutide

ASJC Scopus subject areas

Endocrinology
Endocrinology, Diabetes and Metabolism

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10.1007/s12020-014-0519-0

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One-year treatment with liraglutide improved renal function in patients with type 2 diabetes : a pilot prospective study. / Zavattaro, Marco; Caputo, Marina; Samà, Maria Teresa; Mele, Chiara; Chasseur, Luisa; Marzullo, Paolo; Pagano, Loredana; Mauri, Maria Grazia; Ponziani, Maria Chantal; Aimaretti, Gianluca; Prodam, Flavia.

In: Endocrine, Vol. 50, No. 3, 01.12.2015, p. 620-626.

Research output: Contribution to journal › Article › peer-review

Zavattaro, Marco ; Caputo, Marina ; Samà, Maria Teresa ; Mele, Chiara ; Chasseur, Luisa ; Marzullo, Paolo ; Pagano, Loredana ; Mauri, Maria Grazia ; Ponziani, Maria Chantal ; Aimaretti, Gianluca ; Prodam, Flavia. / One-year treatment with liraglutide improved renal function in patients with type 2 diabetes : a pilot prospective study. In: Endocrine. 2015 ; Vol. 50, No. 3. pp. 620-626.

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AU - Mele, Chiara

AU - Chasseur, Luisa

AU - Marzullo, Paolo

AU - Pagano, Loredana

AU - Mauri, Maria Grazia

AU - Ponziani, Maria Chantal

AU - Aimaretti, Gianluca

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One-year treatment with liraglutide improved renal function in patients with type 2 diabetes: a pilot prospective study

Abstract

Keywords

ASJC Scopus subject areas

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