One-year treatment with liraglutide improved renal function in patients with type 2 diabetes: a pilot prospective study

Marco Zavattaro, Marina Caputo, Maria Teresa Samà, Chiara Mele, Luisa Chasseur, Paolo Marzullo, Loredana Pagano, Maria Grazia Mauri, Maria Chantal Ponziani, Gianluca Aimaretti, Flavia Prodam

Research output: Contribution to journalArticlepeer-review

Abstract

Unlike GLP-1, liraglutide is not cleared by the glomerulus and its pharmacokinetic is not altered in patients with mild renal impairment. The aim of our study was to analyze the effects of liraglutide on renal function in patients with type 2 diabetes. A twelve-month longitudinal prospective post-marketing study was performed. According to eGFR (estimated glomerular filtration rate) calculated with CKD-EPI equation, 84 consecutive patients were divided in Group A (eGFR > 90 ml/min) and Group B (eGFR 1c (p 90 ml/min). At baseline, five patients had pathological microalbuminuria, but at 12 months three of them returned to normal albuminuria (p 

Original languageEnglish
Pages (from-to)620-626
Number of pages7
JournalEndocrine
Volume50
Issue number3
DOIs
Publication statusPublished - Dec 1 2015

Keywords

  • Diabetes
  • Human
  • Kidney
  • Liraglutide

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism

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