Abstract
1. A group of 14 fluctuating Parkinsonian patients underwent the subcutaneous Lisuride treatment, administered by an insulin delivery pump. Clinical response has been studied during a one year period. 2. Some patients (8 out of 14) were in combined therapy, assuming a relative small amount of oral L-Dopa togheter with subcutaneous Lisuride. 3. Lisuride confirmed, also by the subcutaneous route, its antiparkinsonian properties, without any loss of therapeutical efficacy during the 12 month period considered. 4. 7 patients dropped-out from the study, due to psychiatric or systemic side-effects and to "technical" management of the pump. 5. The only 2 patients assuming a 24 hour regimen of Lisuride infusion were among the withdrawn subjects. They were also the only to complain severe psychiatric disturbances.
Original language | English |
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Pages (from-to) | 173-183 |
Number of pages | 11 |
Journal | Progress in Neuro-Psychopharmacology and Biological Psychiatry |
Volume | 13 |
Issue number | 1-2 |
DOIs | |
Publication status | Published - 1989 |
Keywords
- fluctuations
- Lisuride
- pump
- subcutaneous
ASJC Scopus subject areas
- Biological Psychiatry
- Pharmacology