One year treatment with lisuride delivery pump in Parkinson's disease

Stefano Ruggieri, Fabrizio Stocchi, Angelico Carta, Maura Bragoni, Claudio Agostini, Luca Barbato, Alessandro Agnoli

Research output: Contribution to journalArticle

Abstract

1. A group of 14 fluctuating Parkinsonian patients underwent the subcutaneous Lisuride treatment, administered by an insulin delivery pump. Clinical response has been studied during a one year period. 2. Some patients (8 out of 14) were in combined therapy, assuming a relative small amount of oral L-Dopa togheter with subcutaneous Lisuride. 3. Lisuride confirmed, also by the subcutaneous route, its antiparkinsonian properties, without any loss of therapeutical efficacy during the 12 month period considered. 4. 7 patients dropped-out from the study, due to psychiatric or systemic side-effects and to "technical" management of the pump. 5. The only 2 patients assuming a 24 hour regimen of Lisuride infusion were among the withdrawn subjects. They were also the only to complain severe psychiatric disturbances.

Original languageEnglish
Pages (from-to)173-183
Number of pages11
JournalProgress in Neuro-Psychopharmacology and Biological Psychiatry
Volume13
Issue number1-2
DOIs
Publication statusPublished - 1989

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Keywords

  • fluctuations
  • Lisuride
  • pump
  • subcutaneous

ASJC Scopus subject areas

  • Biological Psychiatry
  • Pharmacology

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