Oneiric stupor: The peculiar behaviour of agrypnia excitata

Pietro Guaraldi, Giovanna Calandra-Buonaura, Rossana Terlizzi, Pasquale Montagna, Elio Lugaresi, Paolo Tinuper, Pietro Cortelli, Federica Provini

Research output: Contribution to journalArticlepeer-review


Agrypnia excitata (AE) is a syndrome characterized by the inability to sleep associated with a generalized motor and autonomic over-activation. AE is caused by a thalamo-limbic system dysfunction and comprises three different conditions: Fatal Familial Insomnia (FFI), Delirium Tremens (DT), and Morvan Syndrome (MS). Oneiric Stupor episodes (OS) are the peculiar motor behaviour of AE. During OS patients perform simple automatic gestures mimicking daily-life activities. This paper is the first description of the different characteristics of OS in two patients with MS and another with FFI, emphasizing the specific clinical features that reliably differentiate OS from REM sleep behaviour disorders.

Original languageEnglish
JournalSleep Medicine
Issue numberSUPPL. 2
Publication statusPublished - Dec 2011


  • Agrypnia excitata
  • Delirium tremens
  • Fatal familial insomnia
  • Morvan syndrome
  • Oneiric stupor
  • REM sleep behaviour disorder

ASJC Scopus subject areas

  • Medicine(all)


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