ONGOING ELECTROENCEPHALOGRAPHIC ACTIVITY ASSOCIATED WITH CORTICAL AROUSAL IN TRANSGENIC PDAPP MICE (hAPP V717F)

Wilhelmus Drinkenburg, Susanna Lopez, Jesper F Bastlund, Ditte Zerlang Christensen, Jan T Pedersen, Angelisa Frasca, Francesco M Noè, Marina Bentivoglio, Paolo F Fabene, Giuseppe Bertini, Valeria Colavito, Sophie Dix, Raffaele Ferri, Regis Bordet, Jill C Richardson, Claudio Babiloni

Research output: Contribution to journalArticle

Abstract

BACKGROUND: It has been shown that theta (6-10 Hz) and delta (1-6 Hz) ongoing electroencephalographic (EEG) rhythms revealed variations in the cortical arousal in C57 Wild Type (WT) mice during cage exploration (active condition) compared to awake quiet behavior (passive condition; IMI PharmaCog project, www.pharmacog.eu).

OBJECTIVE: Test if these EEG rhythms might be abnormal in old PDAPP mice modeling Alzheimer's disease (AD) with a hAPP Indiana V717F mutation (They show abnormal neural transmission, cognitive deficits, and brain accumulation of Aβ1-42).

METHODS: Ongoing EEG rhythms were recorded by a frontoparietal bipolar channel in 15 PDAPP and 23 WT C57 male mice (mean age of 22.8 months ±0.4 and 0.3 standard error, respectively). EEG absolute power (density) was calculated. Frequency and amplitude of individual delta and theta frequency (IDF and ITF) peaks were considered during passive and active states in the wakefulness.

RESULTS: Compared with the WT group, the PDAPP group showed higher frequency of the IDF during the passive condition and lower frequency of the ITF during the active state. Furthermore, the WT but not PDAPP group showed significant changes in the frontoparietal EEG power (IDF, ITF) during active over passive state.

CONCLUSIONS: PDAPP mice were characterized by less changes in the brain arousal during an active state as revealed by frontoparietal EEG rhythms. Future studies will have to cross-validate the present results on large animal groups, clarify the neurophysiological underpinning of the effect, and test if the disease modifying drugs against AD amyloidosis normalize those candiate EEG biomarkers in PDAPP mice.

Original languageEnglish
JournalCurrent Alzheimer Research
DOIs
Publication statusE-pub ahead of print - Jul 4 2017

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Arousal
Transgenic Mice
Alzheimer Disease
Wakefulness
Brain
Amyloidosis
Synaptic Transmission
Biomarkers
Mutation
Pharmaceutical Preparations
Power (Psychology)

Keywords

  • Journal Article

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ONGOING ELECTROENCEPHALOGRAPHIC ACTIVITY ASSOCIATED WITH CORTICAL AROUSAL IN TRANSGENIC PDAPP MICE (hAPP V717F). / Drinkenburg, Wilhelmus; Lopez, Susanna; Bastlund, Jesper F; Christensen, Ditte Zerlang; Pedersen, Jan T; Frasca, Angelisa; Noè, Francesco M; Bentivoglio, Marina; Fabene, Paolo F; Bertini, Giuseppe; Colavito, Valeria; Dix, Sophie; Ferri, Raffaele; Bordet, Regis; Richardson, Jill C; Babiloni, Claudio.

In: Current Alzheimer Research, 04.07.2017.

Research output: Contribution to journalArticle

Drinkenburg, W, Lopez, S, Bastlund, JF, Christensen, DZ, Pedersen, JT, Frasca, A, Noè, FM, Bentivoglio, M, Fabene, PF, Bertini, G, Colavito, V, Dix, S, Ferri, R, Bordet, R, Richardson, JC & Babiloni, C 2017, 'ONGOING ELECTROENCEPHALOGRAPHIC ACTIVITY ASSOCIATED WITH CORTICAL AROUSAL IN TRANSGENIC PDAPP MICE (hAPP V717F)', Current Alzheimer Research. https://doi.org/10.2174/1567205014666170704113405
Drinkenburg, Wilhelmus ; Lopez, Susanna ; Bastlund, Jesper F ; Christensen, Ditte Zerlang ; Pedersen, Jan T ; Frasca, Angelisa ; Noè, Francesco M ; Bentivoglio, Marina ; Fabene, Paolo F ; Bertini, Giuseppe ; Colavito, Valeria ; Dix, Sophie ; Ferri, Raffaele ; Bordet, Regis ; Richardson, Jill C ; Babiloni, Claudio. / ONGOING ELECTROENCEPHALOGRAPHIC ACTIVITY ASSOCIATED WITH CORTICAL AROUSAL IN TRANSGENIC PDAPP MICE (hAPP V717F). In: Current Alzheimer Research. 2017.
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abstract = "BACKGROUND: It has been shown that theta (6-10 Hz) and delta (1-6 Hz) ongoing electroencephalographic (EEG) rhythms revealed variations in the cortical arousal in C57 Wild Type (WT) mice during cage exploration (active condition) compared to awake quiet behavior (passive condition; IMI PharmaCog project, www.pharmacog.eu).OBJECTIVE: Test if these EEG rhythms might be abnormal in old PDAPP mice modeling Alzheimer's disease (AD) with a hAPP Indiana V717F mutation (They show abnormal neural transmission, cognitive deficits, and brain accumulation of Aβ1-42).METHODS: Ongoing EEG rhythms were recorded by a frontoparietal bipolar channel in 15 PDAPP and 23 WT C57 male mice (mean age of 22.8 months ±0.4 and 0.3 standard error, respectively). EEG absolute power (density) was calculated. Frequency and amplitude of individual delta and theta frequency (IDF and ITF) peaks were considered during passive and active states in the wakefulness.RESULTS: Compared with the WT group, the PDAPP group showed higher frequency of the IDF during the passive condition and lower frequency of the ITF during the active state. Furthermore, the WT but not PDAPP group showed significant changes in the frontoparietal EEG power (IDF, ITF) during active over passive state.CONCLUSIONS: PDAPP mice were characterized by less changes in the brain arousal during an active state as revealed by frontoparietal EEG rhythms. Future studies will have to cross-validate the present results on large animal groups, clarify the neurophysiological underpinning of the effect, and test if the disease modifying drugs against AD amyloidosis normalize those candiate EEG biomarkers in PDAPP mice.",
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T1 - ONGOING ELECTROENCEPHALOGRAPHIC ACTIVITY ASSOCIATED WITH CORTICAL AROUSAL IN TRANSGENIC PDAPP MICE (hAPP V717F)

AU - Drinkenburg, Wilhelmus

AU - Lopez, Susanna

AU - Bastlund, Jesper F

AU - Christensen, Ditte Zerlang

AU - Pedersen, Jan T

AU - Frasca, Angelisa

AU - Noè, Francesco M

AU - Bentivoglio, Marina

AU - Fabene, Paolo F

AU - Bertini, Giuseppe

AU - Colavito, Valeria

AU - Dix, Sophie

AU - Ferri, Raffaele

AU - Bordet, Regis

AU - Richardson, Jill C

AU - Babiloni, Claudio

N1 - Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.org.

PY - 2017/7/4

Y1 - 2017/7/4

N2 - BACKGROUND: It has been shown that theta (6-10 Hz) and delta (1-6 Hz) ongoing electroencephalographic (EEG) rhythms revealed variations in the cortical arousal in C57 Wild Type (WT) mice during cage exploration (active condition) compared to awake quiet behavior (passive condition; IMI PharmaCog project, www.pharmacog.eu).OBJECTIVE: Test if these EEG rhythms might be abnormal in old PDAPP mice modeling Alzheimer's disease (AD) with a hAPP Indiana V717F mutation (They show abnormal neural transmission, cognitive deficits, and brain accumulation of Aβ1-42).METHODS: Ongoing EEG rhythms were recorded by a frontoparietal bipolar channel in 15 PDAPP and 23 WT C57 male mice (mean age of 22.8 months ±0.4 and 0.3 standard error, respectively). EEG absolute power (density) was calculated. Frequency and amplitude of individual delta and theta frequency (IDF and ITF) peaks were considered during passive and active states in the wakefulness.RESULTS: Compared with the WT group, the PDAPP group showed higher frequency of the IDF during the passive condition and lower frequency of the ITF during the active state. Furthermore, the WT but not PDAPP group showed significant changes in the frontoparietal EEG power (IDF, ITF) during active over passive state.CONCLUSIONS: PDAPP mice were characterized by less changes in the brain arousal during an active state as revealed by frontoparietal EEG rhythms. Future studies will have to cross-validate the present results on large animal groups, clarify the neurophysiological underpinning of the effect, and test if the disease modifying drugs against AD amyloidosis normalize those candiate EEG biomarkers in PDAPP mice.

AB - BACKGROUND: It has been shown that theta (6-10 Hz) and delta (1-6 Hz) ongoing electroencephalographic (EEG) rhythms revealed variations in the cortical arousal in C57 Wild Type (WT) mice during cage exploration (active condition) compared to awake quiet behavior (passive condition; IMI PharmaCog project, www.pharmacog.eu).OBJECTIVE: Test if these EEG rhythms might be abnormal in old PDAPP mice modeling Alzheimer's disease (AD) with a hAPP Indiana V717F mutation (They show abnormal neural transmission, cognitive deficits, and brain accumulation of Aβ1-42).METHODS: Ongoing EEG rhythms were recorded by a frontoparietal bipolar channel in 15 PDAPP and 23 WT C57 male mice (mean age of 22.8 months ±0.4 and 0.3 standard error, respectively). EEG absolute power (density) was calculated. Frequency and amplitude of individual delta and theta frequency (IDF and ITF) peaks were considered during passive and active states in the wakefulness.RESULTS: Compared with the WT group, the PDAPP group showed higher frequency of the IDF during the passive condition and lower frequency of the ITF during the active state. Furthermore, the WT but not PDAPP group showed significant changes in the frontoparietal EEG power (IDF, ITF) during active over passive state.CONCLUSIONS: PDAPP mice were characterized by less changes in the brain arousal during an active state as revealed by frontoparietal EEG rhythms. Future studies will have to cross-validate the present results on large animal groups, clarify the neurophysiological underpinning of the effect, and test if the disease modifying drugs against AD amyloidosis normalize those candiate EEG biomarkers in PDAPP mice.

KW - Journal Article

U2 - 10.2174/1567205014666170704113405

DO - 10.2174/1567205014666170704113405

M3 - Article

C2 - 28675996

JO - Current Alzheimer Research

JF - Current Alzheimer Research

SN - 1567-2050

ER -