Onset and duration of visual acuity improvement after dexamethasone intravitreal implant in eyes with macular edema due to retinal vein occlusion

Baruch D. Kuppermann, Julia A. Haller, Francesco Bandello, Anat Loewenstein, Jenny Jiao, Xiao Yan Li, Scott M. Whitcup

Research output: Contribution to journalArticle

Abstract

PURPOSE:: To evaluate the onset and duration of improvement in best-corrected visual acuity (BCVA) in eyes treated with dexamethasone intravitreal implant 0.7 mg (DEX implant) for macular edema after branch or central retinal vein occlusion. METHODS:: Post hoc analysis of data from 2 previously reported multicenter, 6-month, randomized sham-controlled clinical trials. Patients received a single DEX implant (n = 427) or sham procedure (n = 426) in the study eye. The primary endpoint was the percentage of eyes with 15-letter improvement in BCVA from baseline at postimplant Day 7. RESULTS:: The baseline mean BCVA was 20/80. At Day 7, 10.3% of DEX implant-treated eyes versus 4.0% of sham-treated eyes (P <0.001) had 15-letter improvement in the BCVA, and 27.2% of DEX implant-treated eyes versus 10.6% of sham-treated eyes had 10-letter improvement (P <0.001). The mean improvement at Day 7 was 5.3 letters (branch retinal vein occlusion, 5.1; and central retinal vein occlusion, 5.8) with DEX implant and 1.6 letters (branch retinal vein occlusion, 2.3; and central retinal vein occlusion, 0.1) with sham (P <0.001). The mean time from initial observation of 15-letter BCVA gain to the last observation of 15-letter BCVA gain was 70 days. CONCLUSION:: Dexamethasone intravitreal implant treatment led to improvement in BCVA compared with sham procedure as early as postimplant Day 7. The duration of 3-line improvement was typically 2 to 3 months.

Original languageEnglish
Pages (from-to)1743-1749
Number of pages7
JournalRetina
Volume34
Issue number9
DOIs
Publication statusPublished - 2014

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Keywords

  • Corticosteroids
  • Duration of effect
  • Intravitreal injections
  • Macular edema
  • Onset of effect
  • Retinal vein occlusion
  • Therapy
  • Visual acuity

ASJC Scopus subject areas

  • Ophthalmology
  • Medicine(all)

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