Onset and spread of dyskinesias and motor symptoms in Parkinson's disease

Giovanni Fabbrini, Giovanni Defazio, Carlo Colosimo, Antonio Suppa, Maria Bloise, Alfredo Berardelli

Research output: Contribution to journalArticlepeer-review


We retrospectively investigated in consecutive Parkinson's disease (PD) outpatients the relationship between the body region in which LID first appeared and the body region where Parkinsonian motor symptoms started. We also studied the spread of LID and motor symptoms to other body parts during the progression of PD. Of the 307 PD patients investigated, 99 with LID were enrolled in the study. In these 99 patients, LID started unilaterally in the limbs in 44, bilaterally in the limbs in 26, and in craniocervical region in 29, whereas motor symptoms invariably started in the limbs. LID and motor symptoms started in the same body region in less than half of the patients studied. Of the 99 patients studied, 69 had LID spread to at least another body region during the course of their disease. In this group, clinical examination yielded a significantly different distribution of LID and motor symptoms. These findings suggest that the onset and spread of LID and motor symptoms may follow different anatomical patterns.

Original languageEnglish
Pages (from-to)2091-2096
Number of pages6
JournalMovement Disorders
Issue number14
Publication statusPublished - Oct 30 2009


  • Basal ganglia
  • Dyskinesias
  • L-dopa
  • Parkinson disease

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology


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