Onset of type 1 diabetes mellitus during peginterferon α-2b plus ribavirin treatment for chronic hepatitis C

Raffaele Cozzolongo, Corrado Betterle, Paolo Fabris, Maria Paola Albergoni, Elsa Lanzilotta, Onofrio G. Manghisi

Research output: Contribution to journalArticle

Abstract

A 61-year-old man was observed to develop type 1 diabetes mellitus following a 3-month treatment with recombinant α-2b peginterferon combined with ribavirin for chronic hepatitis C. Serum samples, collected before the start of therapy and 2 months after the diagnosis of diabetes mellitus, revealed islet-cell antibodies at a titer of 20 and 40 JDF-U, respectively, and glutamic acid decarboxylase autoantibodies at a value of 76.5 and 196 IU/ml, respectively. Antibodies to second islet autoantigen were persistently negative. HLA class II typing revealed the presence of DRB1*04/DRB1*14, DQA1*0303-0104 and DQB1*04-0503 alleles. Eight months after the onset of type 1 diabetes mellitus, the patient is still receiving 30 IU insulin daily; the liver function tests are normal and serum hepatitis C virus RNA is negative. These data confirm that, in patients with potential diabetes mellitus, the disease may become manifest as a side-effect during therapy with peginterferon-α plus ribavirin. The patient as a candidate for interferon treatment should therefore be investigated, in addition to thyroid autoimmunity, also for pancreatic autoantibodies before starting therapy.

Original languageEnglish
Pages (from-to)689-692
Number of pages4
JournalEuropean Journal of Gastroenterology and Hepatology
Volume18
Issue number6
Publication statusPublished - Jun 2006

Keywords

  • Autoimmunity
  • Hepatitis C
  • Peginterferon plus ribavirin
  • Type 1 diabetes mellitus

ASJC Scopus subject areas

  • Gastroenterology

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