Ontogenetic development of neostriatal dopamine receptors in the rat

P. F. Spano, K. Kumakura, S. Govoni, M. Trabucchi

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The actions of dopamine and apomorphine on the kinetic properties of striatal adenylate cyclase were investigated during ontogenesis in the rat. The maximum stimulatory effect of dopamine (5 x 10-5M) was constant from birth to maturity (1 to 60 days of age). In contrast, the stimulatory effect elicited by apomorphine (5 x 10-5M) was almost the same as that of dopamine in 6 day old rats, but it declined during maturation reaching 50% of the initial value at 60 days of age. The apparent K(m) value for dopamine did not change during development, while the K(m) for apomorphine was higher in the adult than in the newborn. Apomorphine appeared to have a greater affinity than dopamine for the striatal adenylate cyclase both in adult and newborn rats.

Original languageEnglish
Pages (from-to)621-624
Number of pages4
JournalJournal of Neurochemistry
Issue number2
Publication statusPublished - 1976

ASJC Scopus subject areas

  • Biochemistry
  • Cellular and Molecular Neuroscience


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