Ontogenetic development of neostriatal dopamine receptors in the rat

P. F. Spano, K. Kumakura, S. Govoni, M. Trabucchi

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

The actions of dopamine and apomorphine on the kinetic properties of striatal adenylate cyclase were investigated during ontogenesis in the rat. The maximum stimulatory effect of dopamine (5 x 10-5M) was constant from birth to maturity (1 to 60 days of age). In contrast, the stimulatory effect elicited by apomorphine (5 x 10-5M) was almost the same as that of dopamine in 6 day old rats, but it declined during maturation reaching 50% of the initial value at 60 days of age. The apparent K(m) value for dopamine did not change during development, while the K(m) for apomorphine was higher in the adult than in the newborn. Apomorphine appeared to have a greater affinity than dopamine for the striatal adenylate cyclase both in adult and newborn rats.

Original languageEnglish
Pages (from-to)621-624
Number of pages4
JournalJournal of Neurochemistry
Volume27
Issue number2
Publication statusPublished - 1976

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Dopamine Receptors
Apomorphine
Rats
Dopamine
Corpus Striatum
Adenylyl Cyclases
Parturition
Kinetics

ASJC Scopus subject areas

  • Biochemistry
  • Cellular and Molecular Neuroscience

Cite this

Spano, P. F., Kumakura, K., Govoni, S., & Trabucchi, M. (1976). Ontogenetic development of neostriatal dopamine receptors in the rat. Journal of Neurochemistry, 27(2), 621-624.

Ontogenetic development of neostriatal dopamine receptors in the rat. / Spano, P. F.; Kumakura, K.; Govoni, S.; Trabucchi, M.

In: Journal of Neurochemistry, Vol. 27, No. 2, 1976, p. 621-624.

Research output: Contribution to journalArticle

Spano, PF, Kumakura, K, Govoni, S & Trabucchi, M 1976, 'Ontogenetic development of neostriatal dopamine receptors in the rat', Journal of Neurochemistry, vol. 27, no. 2, pp. 621-624.
Spano PF, Kumakura K, Govoni S, Trabucchi M. Ontogenetic development of neostriatal dopamine receptors in the rat. Journal of Neurochemistry. 1976;27(2):621-624.
Spano, P. F. ; Kumakura, K. ; Govoni, S. ; Trabucchi, M. / Ontogenetic development of neostriatal dopamine receptors in the rat. In: Journal of Neurochemistry. 1976 ; Vol. 27, No. 2. pp. 621-624.
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