Ontogeny of CD40 expression by activated peripheral blood lymphocytes in humans

Duilio Brugnoni, Paolo Airò, Daniel Graf, Massimo Marconi, Chiara Molinari, Debora Braga, Fabio Malacarne, Annarosa Soresina, Alberto G. Ugazio, Roberto Cattaneo, Richard A. Kroczek, Luigi D. Notarangelo

Research output: Contribution to journalArticlepeer-review


The CD40 ligand (CD40L) is a molecule expressed by activated T cells which plays a critical role in the regulation of B-cell responses, including differentiation into Ig-producing cells. Using the specific monoclonal antibody TRAP1 we have evaluated the ontogeny of CD40L expression in 97 normal individuals between birth and 50 years of age. The expression of CD40L is a function of age; it is severely reduced at birth, progressively increases during the first months of life, and reaches a plateau in the second decade. This progressive attainment of the ability to express CD40L is due to a process of maturation of the CD4+ subset, being significantly correlated with the expression of the CD45RO antigen.

Original languageEnglish
Pages (from-to)27-30
Number of pages4
JournalImmunology Letters
Issue number1-2
Publication statusPublished - Jan 1996


  • CD40L
  • Memory cell
  • Neonate
  • Ontogeny of the immune system

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy


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