Abstract
The ontogeny of I-Ak antigens in murine tissues of nonlymphoid origin has been evaluated by reacting acetone-fixed cryostat sections of embryonic, neonate, and adult tissues with the MoAb 10-2.16 in indirect immunofluorescence. Thymus dendritic cells appear to be the first to express I-Ak antigens which become detectable only after birth in skin Langerhans cells, gastrointestinal epithelium, septal cells in lung alveoli, and some endothelia. The full expression of I-Ak antigens as detected in adult mice is reached only at I month of age.
| Original language | English |
|---|---|
| Pages (from-to) | 359-365 |
| Number of pages | 7 |
| Journal | Immunogenetics |
| Volume | 14 |
| Issue number | 5 |
| DOIs | |
| Publication status | Published - Nov 1981 |
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ASJC Scopus subject areas
- Immunology
- Genetics
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Ontogeny of murine I-Ak antigens in tissue of nonlymphoid origin. / Natali, P. G.; Nicotra, M. R.; Giacomini, P.; Pellegrino, M. A.; Ferrone, S.
In: Immunogenetics, Vol. 14, No. 5, 11.1981, p. 359-365.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Ontogeny of murine I-Ak antigens in tissue of nonlymphoid origin
AU - Natali, P. G.
AU - Nicotra, M. R.
AU - Giacomini, P.
AU - Pellegrino, M. A.
AU - Ferrone, S.
PY - 1981/11
Y1 - 1981/11
N2 - The ontogeny of I-Ak antigens in murine tissues of nonlymphoid origin has been evaluated by reacting acetone-fixed cryostat sections of embryonic, neonate, and adult tissues with the MoAb 10-2.16 in indirect immunofluorescence. Thymus dendritic cells appear to be the first to express I-Ak antigens which become detectable only after birth in skin Langerhans cells, gastrointestinal epithelium, septal cells in lung alveoli, and some endothelia. The full expression of I-Ak antigens as detected in adult mice is reached only at I month of age.
AB - The ontogeny of I-Ak antigens in murine tissues of nonlymphoid origin has been evaluated by reacting acetone-fixed cryostat sections of embryonic, neonate, and adult tissues with the MoAb 10-2.16 in indirect immunofluorescence. Thymus dendritic cells appear to be the first to express I-Ak antigens which become detectable only after birth in skin Langerhans cells, gastrointestinal epithelium, septal cells in lung alveoli, and some endothelia. The full expression of I-Ak antigens as detected in adult mice is reached only at I month of age.
UR - http://www.scopus.com/inward/record.url?scp=0019791498&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0019791498&partnerID=8YFLogxK
U2 - 10.1007/BF00373316
DO - 10.1007/BF00373316
M3 - Article
C2 - 7037629
AN - SCOPUS:0019791498
VL - 14
SP - 359
EP - 365
JO - Immunogenetics
JF - Immunogenetics
SN - 0093-7711
IS - 5
ER -