Abstract
The ontogeny of I-Ak antigens in murine tissues of nonlymphoid origin has been evaluated by reacting acetone-fixed cryostat sections of embryonic, neonate, and adult tissues with the MoAb 10-2.16 in indirect immunofluorescence. Thymus dendritic cells appear to be the first to express I-Ak antigens which become detectable only after birth in skin Langerhans cells, gastrointestinal epithelium, septal cells in lung alveoli, and some endothelia. The full expression of I-Ak antigens as detected in adult mice is reached only at I month of age.
Original language | English |
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Pages (from-to) | 359-365 |
Number of pages | 7 |
Journal | Immunogenetics |
Volume | 14 |
Issue number | 5 |
DOIs | |
Publication status | Published - Nov 1981 |
ASJC Scopus subject areas
- Immunology
- Genetics