Ontogeny of murine I-Ak antigens in tissue of nonlymphoid origin

P. G. Natali; M. R. Nicotra; P. Giacomini; M. A. Pellegrino; S. Ferrone

doi:10.1007/BF00373316

Ontogeny of murine I-Ak antigens in tissue of nonlymphoid origin

P. G. Natali, M. R. Nicotra, P. Giacomini, M. A. Pellegrino, S. Ferrone

Istituto Regina Elena

Research output: Contribution to journal › Article › peer-review

Abstract

The ontogeny of I-A^k antigens in murine tissues of nonlymphoid origin has been evaluated by reacting acetone-fixed cryostat sections of embryonic, neonate, and adult tissues with the MoAb 10-2.16 in indirect immunofluorescence. Thymus dendritic cells appear to be the first to express I-A^k antigens which become detectable only after birth in skin Langerhans cells, gastrointestinal epithelium, septal cells in lung alveoli, and some endothelia. The full expression of I-A^k antigens as detected in adult mice is reached only at I month of age.

Original language	English
Pages (from-to)	359-365
Number of pages	7
Journal	Immunogenetics
Volume	14
Issue number	5
DOIs	https://doi.org/10.1007/BF00373316
Publication status	Published - Nov 1981

ASJC Scopus subject areas

Immunology
Genetics

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title = "Ontogeny of murine I-Ak antigens in tissue of nonlymphoid origin",

abstract = "The ontogeny of I-Ak antigens in murine tissues of nonlymphoid origin has been evaluated by reacting acetone-fixed cryostat sections of embryonic, neonate, and adult tissues with the MoAb 10-2.16 in indirect immunofluorescence. Thymus dendritic cells appear to be the first to express I-Ak antigens which become detectable only after birth in skin Langerhans cells, gastrointestinal epithelium, septal cells in lung alveoli, and some endothelia. The full expression of I-Ak antigens as detected in adult mice is reached only at I month of age.",

author = "Natali, {P. G.} and Nicotra, {M. R.} and P. Giacomini and Pellegrino, {M. A.} and S. Ferrone",

year = "1981",

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AU - Nicotra, M. R.

AU - Giacomini, P.

AU - Pellegrino, M. A.

AU - Ferrone, S.

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AB - The ontogeny of I-Ak antigens in murine tissues of nonlymphoid origin has been evaluated by reacting acetone-fixed cryostat sections of embryonic, neonate, and adult tissues with the MoAb 10-2.16 in indirect immunofluorescence. Thymus dendritic cells appear to be the first to express I-Ak antigens which become detectable only after birth in skin Langerhans cells, gastrointestinal epithelium, septal cells in lung alveoli, and some endothelia. The full expression of I-Ak antigens as detected in adult mice is reached only at I month of age.

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