Ontogeny of murine I-Ak antigens in tissue of nonlymphoid origin

P. G. Natali, M. R. Nicotra, P. Giacomini, M. A. Pellegrino, S. Ferrone

Research output: Contribution to journalArticlepeer-review


The ontogeny of I-Ak antigens in murine tissues of nonlymphoid origin has been evaluated by reacting acetone-fixed cryostat sections of embryonic, neonate, and adult tissues with the MoAb 10-2.16 in indirect immunofluorescence. Thymus dendritic cells appear to be the first to express I-Ak antigens which become detectable only after birth in skin Langerhans cells, gastrointestinal epithelium, septal cells in lung alveoli, and some endothelia. The full expression of I-Ak antigens as detected in adult mice is reached only at I month of age.

Original languageEnglish
Pages (from-to)359-365
Number of pages7
Issue number5
Publication statusPublished - Nov 1981

ASJC Scopus subject areas

  • Immunology
  • Genetics

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