Ontogeny of murine I-Ak antigens in tissue of nonlymphoid origin

P. G. Natali, M. R. Nicotra, P. Giacomini, M. A. Pellegrino, S. Ferrone

Research output: Contribution to journalArticle

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Abstract

The ontogeny of I-Ak antigens in murine tissues of nonlymphoid origin has been evaluated by reacting acetone-fixed cryostat sections of embryonic, neonate, and adult tissues with the MoAb 10-2.16 in indirect immunofluorescence. Thymus dendritic cells appear to be the first to express I-Ak antigens which become detectable only after birth in skin Langerhans cells, gastrointestinal epithelium, septal cells in lung alveoli, and some endothelia. The full expression of I-Ak antigens as detected in adult mice is reached only at I month of age.

Original languageEnglish
Pages (from-to)359-365
Number of pages7
JournalImmunogenetics
Volume14
Issue number5
DOIs
Publication statusPublished - Nov 1981

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Langerhans Cells
Indirect Fluorescent Antibody Technique
Acetone
Dendritic Cells
Thymus Gland
Endothelium
Epithelium
Parturition
Lung
Skin
I-Ak antigen

ASJC Scopus subject areas

  • Immunology
  • Genetics

Cite this

Natali, P. G., Nicotra, M. R., Giacomini, P., Pellegrino, M. A., & Ferrone, S. (1981). Ontogeny of murine I-Ak antigens in tissue of nonlymphoid origin. Immunogenetics, 14(5), 359-365. https://doi.org/10.1007/BF00373316

Ontogeny of murine I-Ak antigens in tissue of nonlymphoid origin. / Natali, P. G.; Nicotra, M. R.; Giacomini, P.; Pellegrino, M. A.; Ferrone, S.

In: Immunogenetics, Vol. 14, No. 5, 11.1981, p. 359-365.

Research output: Contribution to journalArticle

Natali, PG, Nicotra, MR, Giacomini, P, Pellegrino, MA & Ferrone, S 1981, 'Ontogeny of murine I-Ak antigens in tissue of nonlymphoid origin', Immunogenetics, vol. 14, no. 5, pp. 359-365. https://doi.org/10.1007/BF00373316
Natali, P. G. ; Nicotra, M. R. ; Giacomini, P. ; Pellegrino, M. A. ; Ferrone, S. / Ontogeny of murine I-Ak antigens in tissue of nonlymphoid origin. In: Immunogenetics. 1981 ; Vol. 14, No. 5. pp. 359-365.
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