Ontogeny of secretory immunity: Levels of secretory IgA and natural antibodies in saliva

G. R. Burgio, A. Lanzavecchia, A. Plebani, S. Jayakar, A. G. Ugazio

Research output: Contribution to journalArticlepeer-review

Abstract

In 187 healthy subjects from 2 months to 27 years of age, secretory IgA and free secretory component were assayed in samples of whole saliva obtained before and after stimulation with lemon juice. Antibody titers against Escherichia coli O antigens and against rabbit erythrocytes were also dosed in unstimulated saliva. Secretory IgA, undetectable in newborns, was present in all 2-month-old tested in both unstimulated and stimulated saliva; thereafter secretory IgA levels increased progressively, reaching adult values by 6 to 8 years in unstimulated saliva and already by 2 to 4 years in stimulated saliva. The antibody titers assessed in unstimulated saliva followed a similar pattern also reaching adult values by 6 to 8 years. On the other hand, free secretory component levels showed no significant variation with age in unstimulated saliva whereas a slight increase was observed in the first year of life in stimulated saliva.

Original languageEnglish
Pages (from-to)1111-1114
Number of pages4
JournalPediatric Research
Volume14
Issue number10
Publication statusPublished - 1980

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

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