Ontological enrichment of the genes-to-systems breast cancer database

Federica Viti, Ettore Mosca, Ivan Merelli, Andrea Calabria, Roberta Alfieri, Luciano Milanesi

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Breast cancer research need the development of specific and suitable tools to appropriately manage biomolecular knowledge. The presented work deals with the integrative storage of breast cancer related biological data, in order to promote a system biology approach to this network disease. To increase data standardization and resource integration, annotations maintained in Genes-to-Systems Breast Cancer (G2SBC) database are associated to ontological terms, which provide a hierarchical structure to organize data enabling more effective queries, statistical analysis and semantic web searching. Exploited ontologies, which cover all levels of the molecular environment, from genes to systems, are among the most known and widely used bioinformatics resources. In G2SBC database ontology terms both provide a semantic layer to improve data storage, accessibility and analysis and represent a user friendly instrument to identify relations among biological components.

Original languageEnglish
Title of host publicationCommunications in Computer and Information Science
Pages171-182
Number of pages12
Volume46
DOIs
Publication statusPublished - 2009

Publication series

NameCommunications in Computer and Information Science
Volume46
ISSN (Print)18650929

Keywords

  • Breast cancer
  • Data integration
  • Database
  • Ontologies

ASJC Scopus subject areas

  • Computer Science(all)

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