TY - GEN
T1 - Ontological enrichment of the genes-to-systems breast cancer database
AU - Viti, Federica
AU - Mosca, Ettore
AU - Merelli, Ivan
AU - Calabria, Andrea
AU - Alfieri, Roberta
AU - Milanesi, Luciano
PY - 2009
Y1 - 2009
N2 - Breast cancer research need the development of specific and suitable tools to appropriately manage biomolecular knowledge. The presented work deals with the integrative storage of breast cancer related biological data, in order to promote a system biology approach to this network disease. To increase data standardization and resource integration, annotations maintained in Genes-to-Systems Breast Cancer (G2SBC) database are associated to ontological terms, which provide a hierarchical structure to organize data enabling more effective queries, statistical analysis and semantic web searching. Exploited ontologies, which cover all levels of the molecular environment, from genes to systems, are among the most known and widely used bioinformatics resources. In G2SBC database ontology terms both provide a semantic layer to improve data storage, accessibility and analysis and represent a user friendly instrument to identify relations among biological components.
AB - Breast cancer research need the development of specific and suitable tools to appropriately manage biomolecular knowledge. The presented work deals with the integrative storage of breast cancer related biological data, in order to promote a system biology approach to this network disease. To increase data standardization and resource integration, annotations maintained in Genes-to-Systems Breast Cancer (G2SBC) database are associated to ontological terms, which provide a hierarchical structure to organize data enabling more effective queries, statistical analysis and semantic web searching. Exploited ontologies, which cover all levels of the molecular environment, from genes to systems, are among the most known and widely used bioinformatics resources. In G2SBC database ontology terms both provide a semantic layer to improve data storage, accessibility and analysis and represent a user friendly instrument to identify relations among biological components.
KW - Breast cancer
KW - Data integration
KW - Database
KW - Ontologies
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U2 - 10.1007/978-3-642-04590-5_16
DO - 10.1007/978-3-642-04590-5_16
M3 - Conference contribution
AN - SCOPUS:70350091421
SN - 9783642045899
VL - 46
T3 - Communications in Computer and Information Science
SP - 171
EP - 182
BT - Communications in Computer and Information Science
ER -