Oocyte Retrieval during Laparoscopic Vaginoplasty to Reduce Invasiveness in the Treatment of Mayer-Rokitansky-Küster-Hauser Syndrome

Massimo Candiani, Valeria S. Vanni, Enrico Papaleo, Diana Delprato, Iacopo Tandoi, Valeria Gervasio, Marta Parma, Laura Corti, Serena Girardelli, Luigi Fedele

Research output: Contribution to journalArticle

Abstract

Study Objective: To evaluate the treatment of patients with Mayer-Rokitansky-Küster-Hauser (MRKH) syndrome with a combination of oocyte retrieval and surgical vaginoplasty in a single laparoscopic procedure. Design: A case series. Setting: The study was conducted at 2 tertiary referral facilities for MRKH syndrome in Milan, Italy, between July 2017 and September 2018. Patients: Eleven patients presented with MRKH and required surgical vaginoplasty while expressing a desire for future fertility. Interventions: Two experienced surgeons and an expert in assisted reproductive technology performed concomitant vaginoplasty according to the modified technique of Davydov and laparoscopic oocyte retrieval for gamete cryopreservation. Measurements and Main Results: Before the procedure, patients underwent extensive counseling and gave written consent. At the start of surgery, 10.4 ± 4.4 (mean ± standard deviation [SD]) oocytes were retrieved laparoscopically, and 8.8 ± 3.1 (SD) mean mature oocytes were cryopreserved. After oocyte retrieval, the steps of the modified Davydov technique were followed. The total operative time was 116 ± 16 minutes (mean ± SD), and no intraoperative/postoperative complications were observed. Conclusion: This is the first report of combined oocyte retrieval and vaginoplasty for patients with MRKH syndrome. The approach was found to be feasible in patients with a desire for future fertility. It is our belief that physicians treating patients with MRKH should refer patients to centers with expertise in both vaginoplasty and assisted reproductive technology.

Original languageEnglish
JournalJournal of Minimally Invasive Gynecology
DOIs
Publication statusPublished - Jan 1 2019

Fingerprint

Oocyte Retrieval
Assisted Reproductive Techniques
Therapeutics
Oocytes
Fertility
Cryopreservation
Intraoperative Complications
Operative Time
Germ Cells
Italy
Counseling
Referral and Consultation
Physicians

Keywords

  • Assisted reproductive technology
  • Davydov technique
  • Gamete cryopreservation
  • Mayer-Rokitansky-Küster-Hauser syndrome

ASJC Scopus subject areas

  • Obstetrics and Gynaecology

Cite this

@article{d9f6acc775e14e45bfdc78e03dcba113,
title = "Oocyte Retrieval during Laparoscopic Vaginoplasty to Reduce Invasiveness in the Treatment of Mayer-Rokitansky-K{\"u}ster-Hauser Syndrome",
abstract = "Study Objective: To evaluate the treatment of patients with Mayer-Rokitansky-K{\"u}ster-Hauser (MRKH) syndrome with a combination of oocyte retrieval and surgical vaginoplasty in a single laparoscopic procedure. Design: A case series. Setting: The study was conducted at 2 tertiary referral facilities for MRKH syndrome in Milan, Italy, between July 2017 and September 2018. Patients: Eleven patients presented with MRKH and required surgical vaginoplasty while expressing a desire for future fertility. Interventions: Two experienced surgeons and an expert in assisted reproductive technology performed concomitant vaginoplasty according to the modified technique of Davydov and laparoscopic oocyte retrieval for gamete cryopreservation. Measurements and Main Results: Before the procedure, patients underwent extensive counseling and gave written consent. At the start of surgery, 10.4 ± 4.4 (mean ± standard deviation [SD]) oocytes were retrieved laparoscopically, and 8.8 ± 3.1 (SD) mean mature oocytes were cryopreserved. After oocyte retrieval, the steps of the modified Davydov technique were followed. The total operative time was 116 ± 16 minutes (mean ± SD), and no intraoperative/postoperative complications were observed. Conclusion: This is the first report of combined oocyte retrieval and vaginoplasty for patients with MRKH syndrome. The approach was found to be feasible in patients with a desire for future fertility. It is our belief that physicians treating patients with MRKH should refer patients to centers with expertise in both vaginoplasty and assisted reproductive technology.",
keywords = "Assisted reproductive technology, Davydov technique, Gamete cryopreservation, Mayer-Rokitansky-K{\"u}ster-Hauser syndrome",
author = "Massimo Candiani and Vanni, {Valeria S.} and Enrico Papaleo and Diana Delprato and Iacopo Tandoi and Valeria Gervasio and Marta Parma and Laura Corti and Serena Girardelli and Luigi Fedele",
year = "2019",
month = "1",
day = "1",
doi = "10.1016/j.jmig.2019.02.023",
language = "English",
journal = "Journal of Minimally Invasive Gynecology",
issn = "1553-4650",
publisher = "Elsevier",

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TY - JOUR

T1 - Oocyte Retrieval during Laparoscopic Vaginoplasty to Reduce Invasiveness in the Treatment of Mayer-Rokitansky-Küster-Hauser Syndrome

AU - Candiani, Massimo

AU - Vanni, Valeria S.

AU - Papaleo, Enrico

AU - Delprato, Diana

AU - Tandoi, Iacopo

AU - Gervasio, Valeria

AU - Parma, Marta

AU - Corti, Laura

AU - Girardelli, Serena

AU - Fedele, Luigi

PY - 2019/1/1

Y1 - 2019/1/1

N2 - Study Objective: To evaluate the treatment of patients with Mayer-Rokitansky-Küster-Hauser (MRKH) syndrome with a combination of oocyte retrieval and surgical vaginoplasty in a single laparoscopic procedure. Design: A case series. Setting: The study was conducted at 2 tertiary referral facilities for MRKH syndrome in Milan, Italy, between July 2017 and September 2018. Patients: Eleven patients presented with MRKH and required surgical vaginoplasty while expressing a desire for future fertility. Interventions: Two experienced surgeons and an expert in assisted reproductive technology performed concomitant vaginoplasty according to the modified technique of Davydov and laparoscopic oocyte retrieval for gamete cryopreservation. Measurements and Main Results: Before the procedure, patients underwent extensive counseling and gave written consent. At the start of surgery, 10.4 ± 4.4 (mean ± standard deviation [SD]) oocytes were retrieved laparoscopically, and 8.8 ± 3.1 (SD) mean mature oocytes were cryopreserved. After oocyte retrieval, the steps of the modified Davydov technique were followed. The total operative time was 116 ± 16 minutes (mean ± SD), and no intraoperative/postoperative complications were observed. Conclusion: This is the first report of combined oocyte retrieval and vaginoplasty for patients with MRKH syndrome. The approach was found to be feasible in patients with a desire for future fertility. It is our belief that physicians treating patients with MRKH should refer patients to centers with expertise in both vaginoplasty and assisted reproductive technology.

AB - Study Objective: To evaluate the treatment of patients with Mayer-Rokitansky-Küster-Hauser (MRKH) syndrome with a combination of oocyte retrieval and surgical vaginoplasty in a single laparoscopic procedure. Design: A case series. Setting: The study was conducted at 2 tertiary referral facilities for MRKH syndrome in Milan, Italy, between July 2017 and September 2018. Patients: Eleven patients presented with MRKH and required surgical vaginoplasty while expressing a desire for future fertility. Interventions: Two experienced surgeons and an expert in assisted reproductive technology performed concomitant vaginoplasty according to the modified technique of Davydov and laparoscopic oocyte retrieval for gamete cryopreservation. Measurements and Main Results: Before the procedure, patients underwent extensive counseling and gave written consent. At the start of surgery, 10.4 ± 4.4 (mean ± standard deviation [SD]) oocytes were retrieved laparoscopically, and 8.8 ± 3.1 (SD) mean mature oocytes were cryopreserved. After oocyte retrieval, the steps of the modified Davydov technique were followed. The total operative time was 116 ± 16 minutes (mean ± SD), and no intraoperative/postoperative complications were observed. Conclusion: This is the first report of combined oocyte retrieval and vaginoplasty for patients with MRKH syndrome. The approach was found to be feasible in patients with a desire for future fertility. It is our belief that physicians treating patients with MRKH should refer patients to centers with expertise in both vaginoplasty and assisted reproductive technology.

KW - Assisted reproductive technology

KW - Davydov technique

KW - Gamete cryopreservation

KW - Mayer-Rokitansky-Küster-Hauser syndrome

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SN - 1553-4650

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