Open-chain peptides obtained by acidic hydrolytic cleavage of cyclosporin A

F. Magni, C. Arcelloni, R. Paroni, I. Fermo, P. A. Bonini, M. Del Puppo, A. Manzocchi, M. Galli Kienle

Research output: Contribution to journalArticlepeer-review

Abstract

Hydrolysis of cyclosporin A (CsA) was studied in order to clarify the still undefined point of attack of the acidic degradation. Among ether extractable and water-soluble products formed from CsA in HCl, two open-chain peptides were isolated by high-performance liquid chromatography which were identified as the deca- and nonapeptides deriving from CsA through the hydrolytic cleavage of amino acid residue 11 and both residues 11 and 10, respectively. Identification was carried out by fast atom bombardment tandem mass spectrometry.

Original languageEnglish
Pages (from-to)514-518
Number of pages5
JournalBiological Mass Spectrometry
Volume23
Issue number8
DOIs
Publication statusPublished - Aug 1994

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine

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