Open field behaviours and spatial learning performance in C57BL/6 mice: early stage effects of chronic GM1 ganglioside administration

Sandro Fagioli, Clelia Rossi-Arnaud, Martine Ammassari-Teule

Research output: Contribution to journalArticlepeer-review

Abstract

One month intact C57BL/6 mice were treated with GM1 ganglioside for 3 consecutive weeks. At 2 months of age, treated and control mice were observed in the open-field situation and tested for spatial learning in a radial eight-arm maze. The results showed that, in the open-field, treated mice displayed less freezing but more rearing behavior than control animals. In the radial maze, GM1-treated mice made more correct path choices before the first error within each trial than control mice. However, this improvement was limited to the first stage of training. These results suggest an early stimulating effect of the GM1 ganglioside treatment which could facilitate adaptive reactions to new situations.

Original languageEnglish
Pages (from-to)209-212
Number of pages4
JournalPsychopharmacology
Volume105
Issue number2
DOIs
Publication statusPublished - Oct 1991

Keywords

  • Emotionality
  • GM1 ganglioside
  • Mice
  • Open field
  • Spatial learning

ASJC Scopus subject areas

  • Pharmacology

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