Abstract
Open loop linear parametric modeling approach was applied to describe the variability of the ventricular depolarization and repolarization duration (i.e. the QT interval from the ECG). Several model structures were compared. The model maximizing the goodness of fit describes the QT interval as a linear combination of its own past values plus two exogenous influences (i.e. heart period interval and respiration) and a colored noise. When this model was applied to a protocol imposing a progressive increase of the sympathetic activity and modulation (i.e. the graded head-up tilt), the goodness of fit gradually decreased, thus suggesting a progressive uncoupling between QT duration and heart period that cannot be the result of influences unrelated to heart period changes.
| Original language | English |
|---|---|
| Title of host publication | Proceedings of the 31st Annual International Conference of the IEEE Engineering in Medicine and Biology Society: Engineering the Future of Biomedicine, EMBC 2009 |
| Pages | 6453-6456 |
| Number of pages | 4 |
| DOIs | |
| Publication status | Published - 2009 |
| Event | 31st Annual International Conference of the IEEE Engineering in Medicine and Biology Society: Engineering the Future of Biomedicine, EMBC 2009 - Minneapolis, MN, United States Duration: Sep 2 2009 → Sep 6 2009 |
Other
| Other | 31st Annual International Conference of the IEEE Engineering in Medicine and Biology Society: Engineering the Future of Biomedicine, EMBC 2009 |
|---|---|
| Country | United States |
| City | Minneapolis, MN |
| Period | 9/2/09 → 9/6/09 |
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ASJC Scopus subject areas
- Cell Biology
- Developmental Biology
- Biomedical Engineering
- Medicine(all)
Cite this
Open loop linear parametric modeling of the QT variability. / Porta, Alberto; Tobaldini, Eleonora; Magagnin, Valentina; Bassani, Tito; Gnecchi-Ruscone, Tomaso; Montano, Nicola.
Proceedings of the 31st Annual International Conference of the IEEE Engineering in Medicine and Biology Society: Engineering the Future of Biomedicine, EMBC 2009. 2009. p. 6453-6456 5333541.Research output: Chapter in Book/Report/Conference proceeding › Conference contribution
}
TY - GEN
T1 - Open loop linear parametric modeling of the QT variability
AU - Porta, Alberto
AU - Tobaldini, Eleonora
AU - Magagnin, Valentina
AU - Bassani, Tito
AU - Gnecchi-Ruscone, Tomaso
AU - Montano, Nicola
PY - 2009
Y1 - 2009
N2 - Open loop linear parametric modeling approach was applied to describe the variability of the ventricular depolarization and repolarization duration (i.e. the QT interval from the ECG). Several model structures were compared. The model maximizing the goodness of fit describes the QT interval as a linear combination of its own past values plus two exogenous influences (i.e. heart period interval and respiration) and a colored noise. When this model was applied to a protocol imposing a progressive increase of the sympathetic activity and modulation (i.e. the graded head-up tilt), the goodness of fit gradually decreased, thus suggesting a progressive uncoupling between QT duration and heart period that cannot be the result of influences unrelated to heart period changes.
AB - Open loop linear parametric modeling approach was applied to describe the variability of the ventricular depolarization and repolarization duration (i.e. the QT interval from the ECG). Several model structures were compared. The model maximizing the goodness of fit describes the QT interval as a linear combination of its own past values plus two exogenous influences (i.e. heart period interval and respiration) and a colored noise. When this model was applied to a protocol imposing a progressive increase of the sympathetic activity and modulation (i.e. the graded head-up tilt), the goodness of fit gradually decreased, thus suggesting a progressive uncoupling between QT duration and heart period that cannot be the result of influences unrelated to heart period changes.
UR - http://www.scopus.com/inward/record.url?scp=77951016346&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=77951016346&partnerID=8YFLogxK
U2 - 10.1109/IEMBS.2009.5333541
DO - 10.1109/IEMBS.2009.5333541
M3 - Conference contribution
AN - SCOPUS:77951016346
SN - 9781424432967
SP - 6453
EP - 6456
BT - Proceedings of the 31st Annual International Conference of the IEEE Engineering in Medicine and Biology Society: Engineering the Future of Biomedicine, EMBC 2009
ER -