Open partial horizontal laryngectomies for T3–T4 laryngeal cancer: Prognostic impact of anterior vs. posterior laryngeal compartmentalization

Francesca Del Bon, Cesare Piazza, Davide Lancini, Alberto Paderno, Paolo Bosio, Stefano Taboni, Riccardo Morello, Nausica Montalto, Francesco Missale, Fabiola Incandela, Filippo Marchi, Marta Filauro, Alberto Deganello, Giorgio Peretti, Piero Nicolai

Research output: Contribution to journalArticlepeer-review


Open partial horizontal laryngectomies (OPHLs) are well-established and oncologically safe procedures for intermediate–advanced laryngeal cancers (LC). T–N categories are well-known prognosticators: herein we tested if “anterior” vs. “posterior” tumor location (as defined in respect to the paraglottic space divided according to a plane passing through the arytenoid vocal process, perpendicular to the ipsilateral thyroid lamina) may represent an additional prognostic factor. We analyzed a retrospective cohort of 85 T3–4a glottic LCs, treated by Type II or III OPHL (according to the European Laryngological Society classification) from 2005 to 2017 at two academic institutions. Five-year overall survival (OS), disease-specific survivals (DSS), and recurrence-free survivals (RFS) were compared according to tumor location and pT category. Anterior and posterior tumors were 43.5% and 56.5%, respectively, 78.8% of lesions were T3 and 21.2% were T4a. Five-year OS, DSS, and RFS for T3 were 74.1%, 80.5%, and 63.4%, respectively, and for T4a 71.8%, 71.8%, and 43%, respectively (p not significant). In relation to tumor location, the survival outcomes were 91%, 94.1%, and 72.6%, respectively, for anterior tumors, and 60.3%, 66.3%, and 49.1%, respectively, for posterior lesions (statistically significant differences). These data provide evidence that laryngeal compartmentalization is a valid prognosticator, even more powerful than the pT category.

Original languageEnglish
Article number289
Issue number3
Publication statusPublished - Mar 1 2019


  • Conservative surgery
  • Laryngeal cancer
  • Open partial horizontal laryngectomy
  • Paraglottic space
  • Prognosis

ASJC Scopus subject areas

  • Oncology
  • Cancer Research


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