OpenDose: Open-Access Resource for Nuclear Medicine Dosimetry

Maxime Chauvin, Damian Borys, Francesca Botta, Pawel Bzowski, Jérémie Dabin, Ana M. Denis-Bacelar, Aurélie Desbrée, Nadia Falzone, Boon Quan Lee, Andrea Mairani, Alessandra Malaroda, Gilles Mathieu, Erin McKay, Erick Mora-Ramirez, Andrew P. Robinson, David Sarrut, Lara Struelens, Alex Vergara Gil, Manuel Bardiès

Research output: Contribution to journalArticlepeer-review

Abstract

Radiopharmaceutical dosimetry depends on the localization in space and time of radioactive sources and requires the estimation of the amount of energy emitted by the sources deposited within targets. In particular, when computing resources are not accessible, this task can be performed using precomputed tables of specific absorbed fractions (SAFs) or S values based on dosimetric models. The aim of the OpenDose collaboration is to generate and make freely available a range of dosimetric data and tools. Methods: OpenDose brings together resources and expertise from 18 international teams to produce and compare traceable dosimetric data using 6 of the most popular Monte Carlo codes in radiation transport (EGSnrc/EGS++, FLUKA, GATE, Geant4, MCNP/MCNPX, and PENELOPE). SAFs are uploaded, together with their associated statistical uncertainties, in a relational database. S values are then calculated from monoenergetic SAFs on the basis of the radioisotope decay data presented in International Commission on Radiological Protection Publication 107. Results: The OpenDose collaboration produced SAFs for all source region and target combinations of the 2 International Commission on Radiological Protection Publication 110 adult reference models. SAFs computed from the different Monte Carlo codes were in good agreement at all energies, with SDs below individual statistical uncertainties. Calculated S values were in good agreement with OLINDA/EXM 2.0 (commercial) and IDAC-Dose 2.1 (free) software. A dedicated website (www.opendose.org) has been developed to provide easy and open access to all data. Conclusion: The OpenDose website allows the display and downloading of SAFs and the corresponding S values for 1,252 radionuclides. The OpenDose collaboration, open to new research teams, will extend data production to other dosimetric models and implement new free features, such as online dosimetric tools and patient-specific absorbed dose calculation software, together with educational resources.

Original languageEnglish
Pages (from-to)1514-1519
Number of pages6
JournalJournal of nuclear medicine : official publication, Society of Nuclear Medicine
Volume61
Issue number10
DOIs
Publication statusPublished - Oct 1 2020

Keywords

  • dosimetry
  • Monte Carlo methods
  • nuclear medicine
  • open-access database

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Fingerprint Dive into the research topics of 'OpenDose: Open-Access Resource for Nuclear Medicine Dosimetry'. Together they form a unique fingerprint.

Cite this