Operability of glioblastomas: "sins of action" versus "sins of non-action"

Paolo Ferroli, Marco Schiariti, Gaetano Finocchiaro, Andrea Salmaggi, Melina Castiglione, Francesco Acerbi, Giovanni Tringali, Mariangela Farinotti, Morgan Broggi, Cordella Roberto, Elio Maccagnano, Giovanni Broggi

Research output: Contribution to journalArticlepeer-review


Despite prognosis of glioblastomas is still poor, mounting evidence suggests that more extensive surgical resections are associated with longer life expectancy. However, the surgical indications, at present, are far from uniform and the concept of operability is extremely surgeon-dependant. The results of glioblastoma resection in 104 patients operated on between March 2005 and April 2011 were reviewed with the aim to shed some light on the limits between 'sins of action' (operating upon complex tumors causing a permanent severe deficit) and 'sins of non-action' (considering inoperable tumors that can be resected with good results). Fifty-five patients (54.4 %) (Group 1) presented with a 'disputable' surgical indication because of one or more of the following clinico-radiological aspects: involvement of motor and language areas (39.4 %), deep location (7.7 %), corpus callosum infiltration (13.4 %), or major vessels encasement (8.6 %). Forty-six (42.5 %) patients (Group 2) presented with an 'indisputable' surgical indication (readily accessible tumors in non-eloquent areas). Overall mortality was 2.9 %. The mean overall survival was 19.8 months and not significantly different in the two Groups (20.4 Group 2 and 19.5 months for Group 1; p = 0.7). Patients with GTR and

Original languageEnglish
Pages (from-to)2107-2116
Number of pages10
JournalNeurological Sciences
Issue number12
Publication statusPublished - Dec 2013


  • Glioblastoma
  • Neurosurgery
  • Operability
  • Quality of life
  • Survival

ASJC Scopus subject areas

  • Clinical Neurology
  • Psychiatry and Mental health
  • Dermatology


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