Operationalization of a frailty index in patients with multiple sclerosis: A cross-sectional investigation

Daniele Belvisi, Marco Canevelli, Viola Baione, Maria Chiara Buscarinu, Giulia Pellicciari, Roberta Fantozzi, Armando Creta, Gianluca Cecchi, Gaia Cola, Carolina Gabri Nicoletti, Antonio Cortese, Laura De Giglio, Matteo Tartaglia, Sebastiano Giuseppe Crisafulli, Giuseppe Bruno, Elisabetta Ferraro, Girolama Alessandra Marfia, Diego Centonze, Marco Salvetti, Antonella Conte

Research output: Contribution to journalArticlepeer-review


BACKGROUND: Frailty is an age-related status of increased vulnerability to stressors caused by the accumulation of multiple health deficits. This construct may allow to capture the clinical complexity of patients with multiple sclerosis (MS).

OBJECTIVE: To investigate the relationship between frailty and the clinical manifestations of MS.

METHODS: Patients with MS were consecutively enrolled at five tertiary dedicated services. Disability and fatigue were assessed. The phenotypes of MS were also identified. Frailty was measured using a frailty index (FI), computed by cumulatively considering 42 age-related multidimensional health deficits.

RESULTS: Overall, 745 MS patients (mean age = 48.2 years, standard deviation = 11.7 years; women 68%) were considered. The median FI value was 0.12 (interquartile range = 0.05-0.19) and the 99th percentile was 0.40. FI scores were associated with MS disease duration, disability, fatigue, as well as with the number of previous disease-modifying treatments and current symptomatic therapies. A logistic regression analysis model showed that FI score was independently associated with the secondary progressive phenotype.

CONCLUSION: Frailty is significantly associated with major characteristics of MS. The findings of the present cross-sectional investigation should be explored in future longitudinal studies.

Original languageEnglish
Pages (from-to)1352458520987541
JournalMultiple Sclerosis
Issue number12
Publication statusPublished - Oct 2021


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