Operative mortality after gastric cancer resection and long-term survival differences across Europe

C. Lepage, M. Sant, A. Verdecchia, D. Forman, J. Esteve, J. Faivre, G. Hédelin, M. Velten, G. Launoy, J. Faivre, P. Crosignani, J. W W Coebergh, I. Izarzugaza, C. Martinez-Garcia, V. Pompe-Kirn, M. Primic-Zakelj, M. Zwierko

Research output: Contribution to journalArticle

Abstract

Background: Little is known at a population level about operative mortality after surgery for gastric cancer and whether differences between countries can explain differences in long-term survival. This study compared operative mortality recorded by ten cancer registries in seven European countries. Methods: Non-conditional logistic regression analysis was performed to estimate the independent effect of the studied factors onmortality within 30 days of surgery. A multivariable survival model was employed with and without operative mortality. Results: The overall operative mortality rate in 1611 patients studied was 8.9 (range 5.2-16) per cent. Country of residence was a significant prognostic factor in the multivariable analysis. The likelihood of operative mortality was lower in Italy, France and the UK than in the Netherlands, Spain, Slovenia and Poland. Age, type of gastrectomy and stage at diagnosis were also significant factors. Cancer site was not found to be significant in the multivariable analysis. The overall 5-year relative survival rate varied between 42.0 per cent (Italy) and 24 per cent (Poland); after excluding operative mortality, the 5-year survival rate was 44.3 and 28 per cent respectively. Conclusion: Within Europe, the substantial differences in operative mortality after gastrectomy only partly explain marked differences in survival after gastric cancer resection.

Original languageEnglish
Pages (from-to)235-239
Number of pages5
JournalBritish Journal of Surgery
Volume97
Issue number2
DOIs
Publication statusPublished - Feb 2010

ASJC Scopus subject areas

  • Surgery

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    Lepage, C., Sant, M., Verdecchia, A., Forman, D., Esteve, J., Faivre, J., Hédelin, G., Velten, M., Launoy, G., Faivre, J., Crosignani, P., Coebergh, J. W. W., Izarzugaza, I., Martinez-Garcia, C., Pompe-Kirn, V., Primic-Zakelj, M., & Zwierko, M. (2010). Operative mortality after gastric cancer resection and long-term survival differences across Europe. British Journal of Surgery, 97(2), 235-239. https://doi.org/10.1002/bjs.6865