Ophthalmic artery vasodilation after intranasal estradiol use in postmenopausal women

Marco Matteo Ciccone, Ettore Cicinelli, Alessio Giovanni, Pietro Scicchitano, Michele Gesualdo, Annapaola Zito, Fara Fornarelli, Manuela Locorotondo, Maria Vittoria Cicinelli, Concetta Di Teo, Giuseppe Farinola, Domenico Scrutinio

Research output: Contribution to journalArticlepeer-review


Aim: The study aim was to evaluate the acute hemodynamic effects of intranasal 17-beta-estradiol on ophthalmic arterial circulation in postmenopausal women. Methods: Twenty-one healthy women in natural menopause for at least 6 months (mean age: 53.2± 2.9 years) were investigated. Each patient received 300 μg intranasal 17-beta-estradiol. We evaluated the heart rate, systolic and diastolic blood pressure, ophthalmic artery velocity at systolic and diastolic peak and its flow curve integral (FCI) before and 30, 60 and 180 minutes after the administration of the drug. Results: At all time points, the ophthalmic artery FCI showed statistically significant variations (p

Original languageEnglish
Pages (from-to)1061-1065
Number of pages5
JournalJournal of Atherosclerosis and Thrombosis
Issue number12
Publication statusPublished - 2012


  • Cerebral circulation
  • Estradiol
  • Estrogen therapy
  • Menopause
  • Ophthalmic artery

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Internal Medicine
  • Biochemistry, medical


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