Opioid-dopamine interaction in planaria: A behavioral study

Francesca Passarelli, Angelo Merante, Francesco E. Pontieri, Vito Margotta, Giorgio Venturini, Guido Palladini

Research output: Contribution to journalArticle

33 Citations (Scopus)

Abstract

The behavioral response of planaria to the exposure to selective opioid agonists was studied. The μ agonist [d-ala2, N-methyl-Phe4,Gly5-ol]enkephalin (DAMGO) and the δ agonist [D-Pen2, D-Pen5]enkephalin (DPDPE) failed to alter motor activity at all doses tested. Low doses of the selective κ agonist (±)-trans-U-50-trans-3,4-dichloro-N-methyl-N[2-(1-pyrrodinyl)-cyclohexyl]benzene acetamide methasulphonate (U50, 488) and bremazocine-HCl increased motor activity leading to C-like position (CLP) and screw-like hyperkinesia (SLH). These changes were identical to those seen previously with the exposure to D2 or D1 dopamine receptor agonists, respectively. Higher doses of κ agonists produced the enhancement of CLP and SLH together with robust snake-like movements (SLM). This latter response, that was typical of stimulation of κ opioid receptors, was blocked by co-exposure to naloxone or the selective κ antagonist Nor-binaltorphimine (Nor-BNI). Finally, co-exposure to sulpiride or SH-23390 respectively blocked the CLP or SLH response produced by U50,488 or bremazocine. Our data indicate the presence of κ opioid receptors in planaria and suggest the functional interaction between the opioid and dopamine system in this simple animal model. Copyright (C) 1999 Elsevier Science Inc.

Original languageEnglish
Pages (from-to)51-55
Number of pages5
JournalComparative Biochemistry and Physiology - C Pharmacology Toxicology and Endocrinology
Volume124
Issue number1
DOIs
Publication statusPublished - Sep 1999

Fingerprint

Hyperkinesis
Opioid Analgesics
Dopamine
Opioid Receptors
Motor Activity
D-Penicillamine (2,5)-Enkephalin
Sulpiride
Snakes
Enkephalins
Dopamine Agonists
Naloxone
Benzene
Animal Models
bremazocine

Keywords

  • Behavior
  • Bremazocine
  • Dopamine
  • Nor-BNI
  • Opioids
  • Planaria
  • Receptors
  • U50,488

ASJC Scopus subject areas

  • Immunology
  • Pharmacology

Cite this

Opioid-dopamine interaction in planaria : A behavioral study. / Passarelli, Francesca; Merante, Angelo; Pontieri, Francesco E.; Margotta, Vito; Venturini, Giorgio; Palladini, Guido.

In: Comparative Biochemistry and Physiology - C Pharmacology Toxicology and Endocrinology, Vol. 124, No. 1, 09.1999, p. 51-55.

Research output: Contribution to journalArticle

Passarelli, Francesca ; Merante, Angelo ; Pontieri, Francesco E. ; Margotta, Vito ; Venturini, Giorgio ; Palladini, Guido. / Opioid-dopamine interaction in planaria : A behavioral study. In: Comparative Biochemistry and Physiology - C Pharmacology Toxicology and Endocrinology. 1999 ; Vol. 124, No. 1. pp. 51-55.
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