Opioid modulation of normal and pathological human chromaffin tissue

M. Mannelli, M. Maggi, M. L. DeFeo, M. Boscaro, G. Opocher, F. Mantero, E. Baldi, G. Giusti

Research output: Contribution to journalArticlepeer-review

Abstract

To evaluate whether opioid receptor blockade might modulate sympathetic-adrenal activity, we studied the effects of placebo or naloxone administration on plasma catecholamine (CA) levels in a group of 13 normal subjects and 15 hypertensive patients suspected to have a pheochromocytoma. Diagnostic evaluation confirmed the presence of pheochromocytoma in 9 patients. Among these, 4 had a unilateral epinephrine (E)-secreting tumor, 3 had bilateral E-secreting tumors due to multiple endocrine adenomatosis type IIa, and 2 had a unilateral norepinephrine (NE)-secreting tumor. In each subject studied, CA secretion was evaluated by calculating the area (0-30 min) under the plasma hormone curves after placebo or naloxone administration. In normal subjects naloxone caused a significant increase (P

Original languageEnglish
Pages (from-to)577-582
Number of pages6
JournalJournal of Clinical Endocrinology and Metabolism
Volume62
Issue number3
Publication statusPublished - 1986

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology, Diabetes and Metabolism

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