Opposing circadian rhythms of CD3+, CD4+ and CD3+, CD8+ lymphocyte subpopulations in healthy humans

Gianluigi Mazzoccoli, Angelo De Cata, Antonio Greco, Marcello Damato, Davide Gennaro De Pinto, Marcella Montrano, Nunzia Marzulli, Mariangela Pia Dagostino, Stefano Carughi

Research output: Contribution to journalArticle

Abstract

Lymphocyte subpopulations present circadian variation of some of their subsets and this variation may influence the magnitude and expression of immune responses. The aim of this study was to analyze the dynamics of variation of specific lymphocyte subsets. Lymphocyte subpopulation analyses were performed on blood samples collected every four hours for 24 hours from 15 healthy subjects aged 37-54 years. A clear circadian rhythm was validated for CD8 with acrophase at noon and for CD3 and CD4 with acrophase at night. Specific lymphocyte subsets present different profiles of nyctohemeral changes and this might explain time-related variations of immune responses.

Original languageEnglish
Pages (from-to)111-118
Number of pages8
JournalBiological Rhythm Research
Volume42
Issue number2
DOIs
Publication statusPublished - Apr 2011

Keywords

  • CD4
  • CD8
  • circadian rhythm
  • lymphocyte subpopulation

ASJC Scopus subject areas

  • Physiology
  • Physiology (medical)
  • Ecology, Evolution, Behavior and Systematics

Fingerprint Dive into the research topics of 'Opposing circadian rhythms of CD3+, CD4+ and CD3+, CD8+ lymphocyte subpopulations in healthy humans'. Together they form a unique fingerprint.

  • Cite this