Abstract
HLA-DR2 and namely the allelic variant HLA-DR15 have been associated with lupus nephritis in Caucasoid patients. In this study we investigated the relationships between HLA-class II alleles and lupus nephritis in Italian patients. Two hundreds and forty-four patients, who fulfil the ARA criteria for Systemic Lupus Erythematosus (SLE) were typed for HLA-DRB1*, DQA1*, DQB1* and DPB1* alleles by PCR-SSOP. Seventy-one patients had renal damage, that was assessed by renal biopsy. Glomerulonephritis were classified on the basis of WHO criteria. In our patients, HLA-DQA1*0101 was strongly associated wiyh lupus nephritis (RR=2.82; p
| Original language | English |
|---|---|
| Pages (from-to) | 302 |
| Number of pages | 1 |
| Journal | European Journal of Immunogenetics |
| Volume | 28 |
| Issue number | 2 |
| Publication status | Published - 2001 |
ASJC Scopus subject areas
- Genetics
- Immunology