Opposite effects by HLA-DQA1*01 alleles on the HLA-DRB1*15 associated lupus nephritis

M. Marchini, R. Antonioli, A. Lleo, L. Origgi, M. Caronni, M. Vanoli, R. Scorza

Research output: Contribution to journalArticlepeer-review

Abstract

HLA-DR2 and namely the allelic variant HLA-DR15 have been associated with lupus nephritis in Caucasoid patients. In this study we investigated the relationships between HLA-class II alleles and lupus nephritis in Italian patients. Two hundreds and forty-four patients, who fulfil the ARA criteria for Systemic Lupus Erythematosus (SLE) were typed for HLA-DRB1*, DQA1*, DQB1* and DPB1* alleles by PCR-SSOP. Seventy-one patients had renal damage, that was assessed by renal biopsy. Glomerulonephritis were classified on the basis of WHO criteria. In our patients, HLA-DQA1*0101 was strongly associated wiyh lupus nephritis (RR=2.82; p

Original languageEnglish
Pages (from-to)302
Number of pages1
JournalEuropean Journal of Immunogenetics
Volume28
Issue number2
Publication statusPublished - 2001

ASJC Scopus subject areas

  • Genetics
  • Immunology

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