Opposite effects of interferon-beta on new B and T cell release from production sites in multiple sclerosis patients

Cinzia Zanotti, Marco Chiarini, Federico Serana, Ruggero Capra, Mariarosa Rottoli, Marco Rovaris, Guido Cavaletti, Raffaella Clerici, Monica Rezzonico, Luigi Caimi, Luisa Imberti

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

The release of newly produced B and T lymphocytes from the production sites was analyzed in 30 multiple sclerosis patients treated with interferon-beta by measuring T-cell receptor excision circles and k-deleting recombination excision circles. We found that the therapy induces opposite effects on B- and T-cell mobilization in 33% of patients. New B-cell production, which peaks after 6. months of therapy and then decreases to levels that, however, are still higher than in controls, may cause a renewal of the B-cell compartment. On the contrary, the decreased number of newly produced T lymphocytes observed at 12. months of treatment and the association between reduced thymic output and low peripheral T lymphocytes can be a cause of leukopenia, a frequent side effect of the therapy.

Original languageEnglish
Pages (from-to)147-150
Number of pages4
JournalJournal of Neuroimmunology
Volume240-241
DOIs
Publication statusPublished - Dec 15 2011

Fingerprint

Interferon-beta
Multiple Sclerosis
B-Lymphocytes
T-Lymphocytes
Leukopenia
Therapeutics
T-Cell Antigen Receptor
Genetic Recombination

Keywords

  • Interferon-beta
  • K-deleting recombination excision circles
  • Multiple sclerosis
  • T-cell receptor excision circles

ASJC Scopus subject areas

  • Immunology
  • Clinical Neurology
  • Immunology and Allergy
  • Neurology

Cite this

Opposite effects of interferon-beta on new B and T cell release from production sites in multiple sclerosis patients. / Zanotti, Cinzia; Chiarini, Marco; Serana, Federico; Capra, Ruggero; Rottoli, Mariarosa; Rovaris, Marco; Cavaletti, Guido; Clerici, Raffaella; Rezzonico, Monica; Caimi, Luigi; Imberti, Luisa.

In: Journal of Neuroimmunology, Vol. 240-241, 15.12.2011, p. 147-150.

Research output: Contribution to journalArticle

Zanotti, C, Chiarini, M, Serana, F, Capra, R, Rottoli, M, Rovaris, M, Cavaletti, G, Clerici, R, Rezzonico, M, Caimi, L & Imberti, L 2011, 'Opposite effects of interferon-beta on new B and T cell release from production sites in multiple sclerosis patients', Journal of Neuroimmunology, vol. 240-241, pp. 147-150. https://doi.org/10.1016/j.jneuroim.2011.10.007
Zanotti, Cinzia ; Chiarini, Marco ; Serana, Federico ; Capra, Ruggero ; Rottoli, Mariarosa ; Rovaris, Marco ; Cavaletti, Guido ; Clerici, Raffaella ; Rezzonico, Monica ; Caimi, Luigi ; Imberti, Luisa. / Opposite effects of interferon-beta on new B and T cell release from production sites in multiple sclerosis patients. In: Journal of Neuroimmunology. 2011 ; Vol. 240-241. pp. 147-150.
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AU - Rovaris, Marco

AU - Cavaletti, Guido

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