TY - JOUR
T1 - Opposite effects of interferon-beta on new B and T cell release from production sites in multiple sclerosis patients
AU - Zanotti, Cinzia
AU - Chiarini, Marco
AU - Serana, Federico
AU - Capra, Ruggero
AU - Rottoli, Mariarosa
AU - Rovaris, Marco
AU - Cavaletti, Guido
AU - Clerici, Raffaella
AU - Rezzonico, Monica
AU - Caimi, Luigi
AU - Imberti, Luisa
PY - 2011/12/15
Y1 - 2011/12/15
N2 - The release of newly produced B and T lymphocytes from the production sites was analyzed in 30 multiple sclerosis patients treated with interferon-beta by measuring T-cell receptor excision circles and k-deleting recombination excision circles. We found that the therapy induces opposite effects on B- and T-cell mobilization in 33% of patients. New B-cell production, which peaks after 6. months of therapy and then decreases to levels that, however, are still higher than in controls, may cause a renewal of the B-cell compartment. On the contrary, the decreased number of newly produced T lymphocytes observed at 12. months of treatment and the association between reduced thymic output and low peripheral T lymphocytes can be a cause of leukopenia, a frequent side effect of the therapy.
AB - The release of newly produced B and T lymphocytes from the production sites was analyzed in 30 multiple sclerosis patients treated with interferon-beta by measuring T-cell receptor excision circles and k-deleting recombination excision circles. We found that the therapy induces opposite effects on B- and T-cell mobilization in 33% of patients. New B-cell production, which peaks after 6. months of therapy and then decreases to levels that, however, are still higher than in controls, may cause a renewal of the B-cell compartment. On the contrary, the decreased number of newly produced T lymphocytes observed at 12. months of treatment and the association between reduced thymic output and low peripheral T lymphocytes can be a cause of leukopenia, a frequent side effect of the therapy.
KW - Interferon-beta
KW - K-deleting recombination excision circles
KW - Multiple sclerosis
KW - T-cell receptor excision circles
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U2 - 10.1016/j.jneuroim.2011.10.007
DO - 10.1016/j.jneuroim.2011.10.007
M3 - Article
C2 - 22078237
AN - SCOPUS:83555176327
VL - 240-241
SP - 147
EP - 150
JO - Journal of Neuroimmunology
JF - Journal of Neuroimmunology
SN - 0165-5728
ER -