Abstract
Identification of relevant phenotypes related to neural functioning has yet to receive the needed attention, although behavioral phenotyping, through comparative studies in inbred strains of mice, has produced some major findings (Cabib et al., 2000; Crabbe, 1999; Gerlai, 1996; Lathe, 1996). Central responses to stress play a major psychopathogenic role in the presence of a genetic liability (Fowels, 1992), and mesocortical and mesoacumbens dopamine metabolism and release are the most relevant among these responses (Abercrombie et al., 1989; Cabib and Puglisi-Allegra, 1994; Chrapusta et al., 1997; Di Chiara et al., 1999; Hervé et al., 1979; Imperato et al., 1991). Therefore, in the present study, we assessed strain-dependent differences in mesocortical and mesoaccumbens dopamine responses to a widely utilized stressful procedure (restraint), by comparing mice of the oldest and most studied inbred strains (Cabib et al., 2000): the C57BL/6JIco and DBA/2JIco. We found that stress produced inhibition of mesoaccumbens dopamine release accompanied by a very fast and strong activation of mesocortical dopamine metabolism in C57BL/6JIco mice, and the opposite in mice of the DBA/2JIco strain. These results suggest a genetic control over the balance between mesocortical and mesoaccumbens dopamine responses to stress, and provide a model for pre-clinical studies on molecular genetics of depression.
| Original language | English |
|---|---|
| Pages (from-to) | 627-631 |
| Number of pages | 5 |
| Journal | Neuroscience |
| Volume | 104 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - Jun 14 2001 |
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Keywords
- Animal models
- Inbred mice
- Nucleus accumbens
- Prefrontal cortex
- Stress
ASJC Scopus subject areas
- Neuroscience(all)
Cite this
Opposite genotype-dependent mesocorticolimbic dopamine response to stress. / Ventura, R.; Cabib, S.; Puglisi-Allegra, S.
In: Neuroscience, Vol. 104, No. 3, 14.06.2001, p. 627-631.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Opposite genotype-dependent mesocorticolimbic dopamine response to stress
AU - Ventura, R.
AU - Cabib, S.
AU - Puglisi-Allegra, S.
PY - 2001/6/14
Y1 - 2001/6/14
N2 - Identification of relevant phenotypes related to neural functioning has yet to receive the needed attention, although behavioral phenotyping, through comparative studies in inbred strains of mice, has produced some major findings (Cabib et al., 2000; Crabbe, 1999; Gerlai, 1996; Lathe, 1996). Central responses to stress play a major psychopathogenic role in the presence of a genetic liability (Fowels, 1992), and mesocortical and mesoacumbens dopamine metabolism and release are the most relevant among these responses (Abercrombie et al., 1989; Cabib and Puglisi-Allegra, 1994; Chrapusta et al., 1997; Di Chiara et al., 1999; Hervé et al., 1979; Imperato et al., 1991). Therefore, in the present study, we assessed strain-dependent differences in mesocortical and mesoaccumbens dopamine responses to a widely utilized stressful procedure (restraint), by comparing mice of the oldest and most studied inbred strains (Cabib et al., 2000): the C57BL/6JIco and DBA/2JIco. We found that stress produced inhibition of mesoaccumbens dopamine release accompanied by a very fast and strong activation of mesocortical dopamine metabolism in C57BL/6JIco mice, and the opposite in mice of the DBA/2JIco strain. These results suggest a genetic control over the balance between mesocortical and mesoaccumbens dopamine responses to stress, and provide a model for pre-clinical studies on molecular genetics of depression.
AB - Identification of relevant phenotypes related to neural functioning has yet to receive the needed attention, although behavioral phenotyping, through comparative studies in inbred strains of mice, has produced some major findings (Cabib et al., 2000; Crabbe, 1999; Gerlai, 1996; Lathe, 1996). Central responses to stress play a major psychopathogenic role in the presence of a genetic liability (Fowels, 1992), and mesocortical and mesoacumbens dopamine metabolism and release are the most relevant among these responses (Abercrombie et al., 1989; Cabib and Puglisi-Allegra, 1994; Chrapusta et al., 1997; Di Chiara et al., 1999; Hervé et al., 1979; Imperato et al., 1991). Therefore, in the present study, we assessed strain-dependent differences in mesocortical and mesoaccumbens dopamine responses to a widely utilized stressful procedure (restraint), by comparing mice of the oldest and most studied inbred strains (Cabib et al., 2000): the C57BL/6JIco and DBA/2JIco. We found that stress produced inhibition of mesoaccumbens dopamine release accompanied by a very fast and strong activation of mesocortical dopamine metabolism in C57BL/6JIco mice, and the opposite in mice of the DBA/2JIco strain. These results suggest a genetic control over the balance between mesocortical and mesoaccumbens dopamine responses to stress, and provide a model for pre-clinical studies on molecular genetics of depression.
KW - Animal models
KW - Inbred mice
KW - Nucleus accumbens
KW - Prefrontal cortex
KW - Stress
UR - http://www.scopus.com/inward/record.url?scp=0035859188&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0035859188&partnerID=8YFLogxK
U2 - 10.1016/S0306-4522(01)00160-9
DO - 10.1016/S0306-4522(01)00160-9
M3 - Article
C2 - 11440796
AN - SCOPUS:0035859188
VL - 104
SP - 627
EP - 631
JO - Neuroscience
JF - Neuroscience
SN - 0306-4522
IS - 3
ER -