Opposite patterns of left ventricular remodeling after coronary revascularization in patients with ischemic cardiomyopathy: Role of myocardial viability

Vittoria Rizzello, Don Poldermans, Eric Boersma, Elena Biagini, Arend F L Schinkel, Boudewijn Krenning, Abdou Elhendy, Eleni C. Vourvouri, Fabiola B. Sozzi, Alexander Maat, Fffippo Crea, Jos R T C Roelandt, Jeroen J. Bax

Research output: Contribution to journalArticle

Abstract

Background-In patients with ischemic cardiomyopathy, left ventricular (LV) remodeling is an important prognostic indicator. The precise relation between viable myocardium, revascularization, and ongoing or reversed remodeling is unknown and was evaluated in the present study. Methods and Results-A total of 100 patients with ischemic cardiomyopathy underwent dobutamine stress echocardiography to assess myocardial viability and LV geometry (volumes and shape). At a mean of 10.2 months and 4.5 years after revascularization, resting echocardiography was repeated to evaluate LV remodeling. Long-term follow-up (mean 5±2 years) data were obtained. According to dobutamine stress echocardiography, 44 patients (44%) were defined as viable (≥4 viable segments) and 56 as nonviable. After revascularization, 40 patients (43%) had ongoing LV remodeling and 53 (57%) did not (in 7 patients who died early after revascularization, postoperative echocardiographic evaluation was not available). On multivariable analysis, the number of viable segments was the only predictor of ongoing LV remodeling (OR 0.60, 95% CI 0.48 to 0.75; P

Original languageEnglish
Pages (from-to)2383-2388
Number of pages6
JournalCirculation
Volume110
Issue number16
DOIs
Publication statusPublished - Oct 19 2004

Keywords

  • Cardiomyopathy
  • Remodeling
  • Revascularization

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine

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    Rizzello, V., Poldermans, D., Boersma, E., Biagini, E., Schinkel, A. F. L., Krenning, B., Elhendy, A., Vourvouri, E. C., Sozzi, F. B., Maat, A., Crea, F., Roelandt, J. R. T. C., & Bax, J. J. (2004). Opposite patterns of left ventricular remodeling after coronary revascularization in patients with ischemic cardiomyopathy: Role of myocardial viability. Circulation, 110(16), 2383-2388. https://doi.org/10.1161/01.CIR.0000145115.29952.14