Opposite role of pro-inflammatory alleles in acute myocardial infarction and longevity: Results of studies performed in a Sicilian population

Giuseppina Candore, Carmela Rita Balistreri, Maria Paola Grimaldi, Florinda Listì, Sonya Vasto, Marco Caruso, Gregorio Caimi, Enrico Hoffmann, Giuseppina Colonna-Romano, Domenico Lio, Giuseppe Paolisso, Claudio Franceschi, Calogero Caruso

Research output: Contribution to journalArticle

Abstract

The major trait characterizing offspring in centenarians is a reduction in the prevalence of cardiovascular disease. Because a pro-inflammatory genotype seems to contribute significantly to the risk of coronary heart disease, alleles associated with disease susceptibility would not be included in the genetic background favoring longevity, as suggested by our previous studies on inflammatory cytokines. To confirm whether genotypes of inflammatory molecules play an opposite role in atherosclerosis and longevity, we are studying the role of other proinflammatory alleles, such as pyrin and CCR5, in acute myocardial infarction and longevity. The results support the hypothesis that the genetic background favoring cardiovascular diseases is detrimental to longevity. In addition, they suggest that the centenarian genetic background may be useful for investigating genetic key components of age-associated diseases that are characterized by a multifactorial etiology.

Original languageEnglish
Pages (from-to)270-275
Number of pages6
JournalAnnals of the New York Academy of Sciences
Volume1067
Issue number1
DOIs
Publication statusPublished - May 2006

Keywords

  • AMI
  • CCR5
  • Inflammation
  • Longevity
  • Pyrin

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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  • Cite this

    Candore, G., Balistreri, C. R., Grimaldi, M. P., Listì, F., Vasto, S., Caruso, M., Caimi, G., Hoffmann, E., Colonna-Romano, G., Lio, D., Paolisso, G., Franceschi, C., & Caruso, C. (2006). Opposite role of pro-inflammatory alleles in acute myocardial infarction and longevity: Results of studies performed in a Sicilian population. Annals of the New York Academy of Sciences, 1067(1), 270-275. https://doi.org/10.1196/annals.1354.035