Optic Nerve dysfunction in obstructive sleep apnea: An electrophysiological study

Claudio Liguor, M. G. Palmieri, Mariangela Pierantozzi, Massimo Cesareo, Andrea Romigi, Francesca Izzi, Maria Grazia Marciani, Corrado Oliva, Nicola Biagio Mercuri, Fabio Placidi

Research output: Contribution to journalArticle

Abstract

Study Objectives: The aim of this study was to evaluate the integrity of the visual system in patients affected by obstructive sleep apnea (OSA) by means of electroretinogram (ERG) and visual evoked potential (VEP). Methods: We performed electrophysiological study of the visual system in a population of severe OSA (apnea-hypopnea events/time in bed ≥ 30/h) patients without medical comorbidities compared to a group of healthy controls similar for age, sex, and body mass index. Patients and controls did not have visual impairment or systemic disorders with known influence on the visual system. ERG and VEP were elicited by a reversal pattern generated on a television monitor at low (55') and high (15') spatial frequencies stimulation. Daytime sleepiness was assessed using the Epworth Sleepiness Scale (ESS) in both patients and controls. Results: In comparison with healthy controls (n = 27), patients with OSA (n = 27) showed a significant latency delay coupled with a significant amplitude reduction of P100 wave of VEP at all spatial frequencies in both eyes. No significant differences between groups were detected as concerning ERG components. No correlations were found between polygraphic parameters, ESS scores, or VEP and ERG components in OSA patients. Conclusions: This study documented that patients with OSA, without medical comorbidities, present VEP alteration as documented by lower amplitude and longer latency of the P100 component than healthy controls. These altered electrophysiological findings may be the expression of optic nerve dysfunction provoked by hypoxia, acidosis, hypercarbia and airway obstruction, frequently observed in patients with OSA. Hence, we hypothesize that OSA per se may impair optic nerve function.

Original languageEnglish
Pages (from-to)19-23
Number of pages5
JournalSleep
Volume39
Issue number1
DOIs
Publication statusPublished - 2016

Fingerprint

Obstructive Sleep Apnea
Optic Nerve
Visual Evoked Potentials
Comorbidity
Hypercapnia
Vision Disorders
Television
Apnea
Airway Obstruction
Acidosis
Body Mass Index
Control Groups
Population

Keywords

  • ERG
  • Optic nerve
  • OSA
  • VEP
  • Visual system

ASJC Scopus subject areas

  • Physiology (medical)
  • Clinical Neurology

Cite this

Liguor, C., Palmieri, M. G., Pierantozzi, M., Cesareo, M., Romigi, A., Izzi, F., ... Placidi, F. (2016). Optic Nerve dysfunction in obstructive sleep apnea: An electrophysiological study. Sleep, 39(1), 19-23. https://doi.org/10.5665/sleep.5308

Optic Nerve dysfunction in obstructive sleep apnea : An electrophysiological study. / Liguor, Claudio; Palmieri, M. G.; Pierantozzi, Mariangela; Cesareo, Massimo; Romigi, Andrea; Izzi, Francesca; Marciani, Maria Grazia; Oliva, Corrado; Mercuri, Nicola Biagio; Placidi, Fabio.

In: Sleep, Vol. 39, No. 1, 2016, p. 19-23.

Research output: Contribution to journalArticle

Liguor, C, Palmieri, MG, Pierantozzi, M, Cesareo, M, Romigi, A, Izzi, F, Marciani, MG, Oliva, C, Mercuri, NB & Placidi, F 2016, 'Optic Nerve dysfunction in obstructive sleep apnea: An electrophysiological study', Sleep, vol. 39, no. 1, pp. 19-23. https://doi.org/10.5665/sleep.5308
Liguor, Claudio ; Palmieri, M. G. ; Pierantozzi, Mariangela ; Cesareo, Massimo ; Romigi, Andrea ; Izzi, Francesca ; Marciani, Maria Grazia ; Oliva, Corrado ; Mercuri, Nicola Biagio ; Placidi, Fabio. / Optic Nerve dysfunction in obstructive sleep apnea : An electrophysiological study. In: Sleep. 2016 ; Vol. 39, No. 1. pp. 19-23.
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