Optic nerve involvement in acute lymphoblastic leukemia

A. Camera, G. Piccirillo, G. Cennamo, F. Tranfa, N. Rosa, F. Frigeri, V. Martinelli, B. Rotoli

Research output: Contribution to journalArticlepeer-review


Leukemic infiltration of the optic nerve is rare. We describe the diagnostic assessment and the outcome in two adult patients suffering from acute lymphoblastic leukemia with T phe-notype. In both cases the leukemic involvement of the eye was observed as an isolated ex-tramedullary relapse followed after several months by hematological relapse. CT and MRI scans were negative, while an A-scan echography of the eye clarified the diagnosis. Early radiotherapy caused recovery of visual acuity in one case. A-scan echography is the most sensitive investigation for the early recognition of ocular localization in acute leukemias.

Original languageEnglish
Pages (from-to)153-155
Number of pages3
JournalLeukemia and Lymphoma
Issue number1-2
Publication statusPublished - 1993


  • Acute lymphoblastic leukemia
  • Ocular echography
  • Optic nerve localization

ASJC Scopus subject areas

  • Hematology
  • Oncology
  • Cancer Research


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