Optical coherence tomographic hyperreflective foci in early stages of diabetic retinopathy

Umberto De Benedetto, Riccardo Sacconi, Luisa Pierro, Rosangela Lattanzio, Francesco Bandello

Research output: Contribution to journalArticle

Abstract

Purpose: To analyze the presence of hyperreflective foci in Type 1 and Type 2 diabetic patients, separately, without clinically significant diabetic macular edema and visual impairment. Methods: Noninvasive, observational prospective study. Seventeen and 19 consecutive Type 1 and Type 2 diabetic patients (33 and 38 eyes), respectively, were recruited. All patients had no clinically significant diabetic macular edema or visual impairment. Two age-and sex-matched control groups were also included. Patients underwent an ophthalmologic examination including spectral domain optical coherence tomography. Hyperreflective foci were counted considering horizontal B-scan passing through the fovea. Results: On spectral domain optical coherence tomography, patients affected by Type 1 and Type 2 diabetes had a mean of 7.5 ± 4.6 and 9.9 ± 4.5 hyperreflective foci, respectively. Subjects of control groups had a mean of 0.9 ± 0.8 and 1.7 ± 1.5 hyperreflective foci, respectively. Hyperreflective foci amount was statistically different between Type 1 and Type 2 diabetic groups (P 0.032) and significantly higher in diabetic patients than in controls (P <0.001). Hyperreflective foci amount was significantly higher in diabetic patients with a poor quality glycometabolic control (P <0.001 and P 0.016) or affected by hypertension (P 0.008). Conclusion: We reported the presence of hyperreflective foci in diabetic patients without diabetic macular edema and visual impairment. This spectral domain optical coherence tomography finding might be a useful marker for the diagnosis and the follow-up in the early stage of diabetic retinopathy.

Original languageEnglish
Pages (from-to)449-453
Number of pages5
JournalRetina
Volume35
Issue number3
DOIs
Publication statusPublished - Mar 10 2015

Keywords

  • diabetic retinopathy
  • hyperreflective dots
  • hyperreflective foci
  • SD-OCT

ASJC Scopus subject areas

  • Ophthalmology
  • Medicine(all)

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