Optical coherence tomography and visual evoked potentials: which is more sensitive in multiple sclerosis?

Giovanni Di Maggio, Roberto Santangelo, Simone Guerrieri, Mariangela Bianco, Laura Ferrari, Stefania Medaglini, Mariaemma Rodegher, Bruno Colombo, Lucia Moiola, Raffaella Chieffo, Ubaldo Del Carro, Vittorio Martinelli, Giancarlo Comi, Letizia Leocani

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

OBJECTIVE: To assess the sensitivity of optic coherence tomography (OCT) and visual evoked potentials (VEPs) to visual pathway abnormalities in multiple sclerosis (MS).

METHODS: A total of 40 MS subjects, 28 with optic neuritis (ON) at least 3 months before (bilateral in 5), underwent assessment of visual acuity, Expanded Disability Status Scale (EDSS), OCT and VEPs, the latter quantified with a 0-4 conventional score.

RESULTS: OCT and VEPs were abnormal in 36% and 56% respectively in all eyes (p=0.11), 68% and 86% in eyes with previous ON (p=0.12), and in 19% versus 40% in eyes without ON history (p=0.007). Combining VEP and OCT increased sensitivity to 89% in ON and 44% in non-ON eyes. Considering all eyes, global retinal nerve fibre layer (RNFL) thickness and VEP score were significantly correlated between them (ρ=-0.63, p

CONCLUSIONS: In eyes without ON, VEPs were more frequently abnormal than OCT, while the two techniques showed similar sensitivity in eyes previously affected by ON. The correlation of VEPs and OCT measures with disability prompts further exploration of the two techniques as potential markers of disease burden.

Original languageEnglish
Pages (from-to)1342-1347
Number of pages6
JournalMultiple Sclerosis Journal
Volume20
Issue number10
DOIs
Publication statusPublished - Sep 1 2014

Fingerprint

Visual Evoked Potentials
Optical Coherence Tomography
Optic Neuritis
Multiple Sclerosis
Tomography
Neuritis
Visual Pathways
Nerve Fibers
Visual Acuity

Keywords

  • disability
  • Multiple sclerosis
  • optic coherence tomography
  • optic neuritis
  • spectral domain
  • visual evoked potentials

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Optical coherence tomography and visual evoked potentials : which is more sensitive in multiple sclerosis? / Di Maggio, Giovanni; Santangelo, Roberto; Guerrieri, Simone; Bianco, Mariangela; Ferrari, Laura; Medaglini, Stefania; Rodegher, Mariaemma; Colombo, Bruno; Moiola, Lucia; Chieffo, Raffaella; Del Carro, Ubaldo; Martinelli, Vittorio; Comi, Giancarlo; Leocani, Letizia.

In: Multiple Sclerosis Journal, Vol. 20, No. 10, 01.09.2014, p. 1342-1347.

Research output: Contribution to journalArticle

@article{fad8f62f62e445aaacdaa495ad0fdee9,
title = "Optical coherence tomography and visual evoked potentials: which is more sensitive in multiple sclerosis?",
abstract = "OBJECTIVE: To assess the sensitivity of optic coherence tomography (OCT) and visual evoked potentials (VEPs) to visual pathway abnormalities in multiple sclerosis (MS).METHODS: A total of 40 MS subjects, 28 with optic neuritis (ON) at least 3 months before (bilateral in 5), underwent assessment of visual acuity, Expanded Disability Status Scale (EDSS), OCT and VEPs, the latter quantified with a 0-4 conventional score.RESULTS: OCT and VEPs were abnormal in 36{\%} and 56{\%} respectively in all eyes (p=0.11), 68{\%} and 86{\%} in eyes with previous ON (p=0.12), and in 19{\%} versus 40{\%} in eyes without ON history (p=0.007). Combining VEP and OCT increased sensitivity to 89{\%} in ON and 44{\%} in non-ON eyes. Considering all eyes, global retinal nerve fibre layer (RNFL) thickness and VEP score were significantly correlated between them (ρ=-0.63, pCONCLUSIONS: In eyes without ON, VEPs were more frequently abnormal than OCT, while the two techniques showed similar sensitivity in eyes previously affected by ON. The correlation of VEPs and OCT measures with disability prompts further exploration of the two techniques as potential markers of disease burden.",
keywords = "disability, Multiple sclerosis, optic coherence tomography, optic neuritis, spectral domain, visual evoked potentials",
author = "{Di Maggio}, Giovanni and Roberto Santangelo and Simone Guerrieri and Mariangela Bianco and Laura Ferrari and Stefania Medaglini and Mariaemma Rodegher and Bruno Colombo and Lucia Moiola and Raffaella Chieffo and {Del Carro}, Ubaldo and Vittorio Martinelli and Giancarlo Comi and Letizia Leocani",
year = "2014",
month = "9",
day = "1",
doi = "10.1177/1352458514524293",
language = "English",
volume = "20",
pages = "1342--1347",
journal = "Multiple Sclerosis",
issn = "1352-4585",
publisher = "SAGE Publications Ltd",
number = "10",

}

TY - JOUR

T1 - Optical coherence tomography and visual evoked potentials

T2 - which is more sensitive in multiple sclerosis?

AU - Di Maggio, Giovanni

AU - Santangelo, Roberto

AU - Guerrieri, Simone

AU - Bianco, Mariangela

AU - Ferrari, Laura

AU - Medaglini, Stefania

AU - Rodegher, Mariaemma

AU - Colombo, Bruno

AU - Moiola, Lucia

AU - Chieffo, Raffaella

AU - Del Carro, Ubaldo

AU - Martinelli, Vittorio

AU - Comi, Giancarlo

AU - Leocani, Letizia

PY - 2014/9/1

Y1 - 2014/9/1

N2 - OBJECTIVE: To assess the sensitivity of optic coherence tomography (OCT) and visual evoked potentials (VEPs) to visual pathway abnormalities in multiple sclerosis (MS).METHODS: A total of 40 MS subjects, 28 with optic neuritis (ON) at least 3 months before (bilateral in 5), underwent assessment of visual acuity, Expanded Disability Status Scale (EDSS), OCT and VEPs, the latter quantified with a 0-4 conventional score.RESULTS: OCT and VEPs were abnormal in 36% and 56% respectively in all eyes (p=0.11), 68% and 86% in eyes with previous ON (p=0.12), and in 19% versus 40% in eyes without ON history (p=0.007). Combining VEP and OCT increased sensitivity to 89% in ON and 44% in non-ON eyes. Considering all eyes, global retinal nerve fibre layer (RNFL) thickness and VEP score were significantly correlated between them (ρ=-0.63, pCONCLUSIONS: In eyes without ON, VEPs were more frequently abnormal than OCT, while the two techniques showed similar sensitivity in eyes previously affected by ON. The correlation of VEPs and OCT measures with disability prompts further exploration of the two techniques as potential markers of disease burden.

AB - OBJECTIVE: To assess the sensitivity of optic coherence tomography (OCT) and visual evoked potentials (VEPs) to visual pathway abnormalities in multiple sclerosis (MS).METHODS: A total of 40 MS subjects, 28 with optic neuritis (ON) at least 3 months before (bilateral in 5), underwent assessment of visual acuity, Expanded Disability Status Scale (EDSS), OCT and VEPs, the latter quantified with a 0-4 conventional score.RESULTS: OCT and VEPs were abnormal in 36% and 56% respectively in all eyes (p=0.11), 68% and 86% in eyes with previous ON (p=0.12), and in 19% versus 40% in eyes without ON history (p=0.007). Combining VEP and OCT increased sensitivity to 89% in ON and 44% in non-ON eyes. Considering all eyes, global retinal nerve fibre layer (RNFL) thickness and VEP score were significantly correlated between them (ρ=-0.63, pCONCLUSIONS: In eyes without ON, VEPs were more frequently abnormal than OCT, while the two techniques showed similar sensitivity in eyes previously affected by ON. The correlation of VEPs and OCT measures with disability prompts further exploration of the two techniques as potential markers of disease burden.

KW - disability

KW - Multiple sclerosis

KW - optic coherence tomography

KW - optic neuritis

KW - spectral domain

KW - visual evoked potentials

UR - http://www.scopus.com/inward/record.url?scp=84945275652&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84945275652&partnerID=8YFLogxK

U2 - 10.1177/1352458514524293

DO - 10.1177/1352458514524293

M3 - Article

C2 - 24591532

AN - SCOPUS:84945275652

VL - 20

SP - 1342

EP - 1347

JO - Multiple Sclerosis

JF - Multiple Sclerosis

SN - 1352-4585

IS - 10

ER -