Optical Coherence Tomography Angiography in Neurodegenerative Disorders dagger

Marco Pellegrini; Aldo Vagge; Lorenzo Ferro Desideri; Federico Bernabei; Giacinto Triolo; Rodolfo Mastropasqua; Chiara Del Noce; Enrico Borrelli; Riccardo Sacconi; Claudio Iovino; Antonio Di Zazzo; Matteo Forlini; Giuseppe Giannaccare

doi:10.3390/jcm9061706

Optical Coherence Tomography Angiography in Neurodegenerative Disorders dagger

Marco Pellegrini, Aldo Vagge, Lorenzo Ferro Desideri, Federico Bernabei, Giacinto Triolo, Rodolfo Mastropasqua, Chiara Del Noce, Enrico Borrelli, Riccardo Sacconi, Claudio Iovino, Antonio Di Zazzo, Matteo Forlini, Giuseppe Giannaccare

Research output: Contribution to journal › Article › peer-review

Abstract

Retinal microcirculation shares similar features with cerebral small blood vessels. Thus, the retina may be considered an accessible `window' to detect the microvascular damage occurring in the setting of neurodegenerative disorders. Optical coherence tomography angiography (OCT-A) is a non-invasive imaging modality providing depth resolved images of blood flow in the retina, choroid, and optic nerve. In this review, we summarize the current literature on the application of OCT-A in glaucoma and central nervous system conditions such as Alzheimer's disease, Parkinson's disease, and multiple sclerosis. Future directions aiming at evaluating whether OCT-A can be an additional biomarker for the early diagnosis and monitoring of neurodegenerative disorders are also discussed.

Original language	English
Journal	Journal of Clinical Medicine
Volume	9
Issue number	6
DOIs	https://doi.org/10.3390/jcm9061706
Publication status	Published - 2020

Keywords

NEUROSCIENZE
REVIEW
RIS

Access to Document

10.3390/jcm9061706

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Optical Coherence Tomography Angiography in Neurodegenerative Disorders dagger. / Pellegrini, Marco; Vagge, Aldo; Ferro Desideri, Lorenzo; Bernabei, Federico; Triolo, Giacinto; Mastropasqua, Rodolfo; Del Noce, Chiara; Borrelli, Enrico; Sacconi, Riccardo; Iovino, Claudio; Di Zazzo, Antonio; Forlini, Matteo; Giannaccare, Giuseppe.

In: Journal of Clinical Medicine, Vol. 9, No. 6, 2020.

Research output: Contribution to journal › Article › peer-review

Pellegrini, Marco ; Vagge, Aldo ; Ferro Desideri, Lorenzo ; Bernabei, Federico ; Triolo, Giacinto ; Mastropasqua, Rodolfo ; Del Noce, Chiara ; Borrelli, Enrico ; Sacconi, Riccardo ; Iovino, Claudio ; Di Zazzo, Antonio ; Forlini, Matteo ; Giannaccare, Giuseppe. / Optical Coherence Tomography Angiography in Neurodegenerative Disorders dagger. In: Journal of Clinical Medicine. 2020 ; Vol. 9, No. 6.

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abstract = "Retinal microcirculation shares similar features with cerebral small blood vessels. Thus, the retina may be considered an accessible `window' to detect the microvascular damage occurring in the setting of neurodegenerative disorders. Optical coherence tomography angiography (OCT-A) is a non-invasive imaging modality providing depth resolved images of blood flow in the retina, choroid, and optic nerve. In this review, we summarize the current literature on the application of OCT-A in glaucoma and central nervous system conditions such as Alzheimer's disease, Parkinson's disease, and multiple sclerosis. Future directions aiming at evaluating whether OCT-A can be an additional biomarker for the early diagnosis and monitoring of neurodegenerative disorders are also discussed.",

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AU - Pellegrini, Marco

AU - Vagge, Aldo

AU - Ferro Desideri, Lorenzo

AU - Bernabei, Federico

AU - Triolo, Giacinto

AU - Mastropasqua, Rodolfo

AU - Del Noce, Chiara

AU - Borrelli, Enrico

AU - Sacconi, Riccardo

AU - Iovino, Claudio

AU - Di Zazzo, Antonio

AU - Forlini, Matteo

AU - Giannaccare, Giuseppe

PY - 2020

Y1 - 2020

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AB - Retinal microcirculation shares similar features with cerebral small blood vessels. Thus, the retina may be considered an accessible `window' to detect the microvascular damage occurring in the setting of neurodegenerative disorders. Optical coherence tomography angiography (OCT-A) is a non-invasive imaging modality providing depth resolved images of blood flow in the retina, choroid, and optic nerve. In this review, we summarize the current literature on the application of OCT-A in glaucoma and central nervous system conditions such as Alzheimer's disease, Parkinson's disease, and multiple sclerosis. Future directions aiming at evaluating whether OCT-A can be an additional biomarker for the early diagnosis and monitoring of neurodegenerative disorders are also discussed.

KW - NEUROSCIENZE

KW - REVIEW

KW - RIS

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DO - 10.3390/jcm9061706

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VL - 9

JO - Journal of Clinical Medicine

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