Optical coherence tomography angiography of the peripapillary retina and optic nerve head in dominant optic atrophy

Nicole Balducci; Antonio P. Ciardella; R Gattegna; Q Zhou; Maria Lucia Cascavilla; C La Morgia; G Savini; V Parisi; F Bandello; V Carelli; Piero Barboni

doi:10.1016/j.mito.2017.03.002

Optical coherence tomography angiography of the peripapillary retina and optic nerve head in dominant optic atrophy

Nicole Balducci, Antonio P. Ciardella, R Gattegna, Q Zhou, Maria Lucia Cascavilla, C La Morgia, G Savini, V Parisi, F Bandello, V Carelli, Piero Barboni

Research output: Contribution to journal › Article › peer-review

Abstract

Peripapillar and nerve head vessel density (VD) was measured in 10 patients affected by Dominant optic atrophy (DOA) using optical coherence tomography angiography (OCT-A) and compared to the measurements of 15 age- and gender-matched controls. DOA patients showed VD reduction, mostly in the temporal and inferotemporal peripapillary sectors, according to the preferential involvement of the papillomacular bundle. Despite poor best-corrected visual acuity (BCVA), OCT-A revealed good repeatability. VD correlated with functional (mean deviation of visual field and BCVA) and structural (retinal nerve fiber layer thickness) parameters and could be a non-invasive, quantitative tool for the monitoring of the disease and of the therapeutic approaches. Copyright Â© 2017 Elsevier B.V. and Mitochondria Research Society. All rights reserved.

Original language	English
Pages (from-to)	60-65
Number of pages	6
Journal	Mitochondrion
Volume	36
Issue number	5
DOIs	https://doi.org/10.1016/j.mito.2017.03.002
Publication status	Published - 2017

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title = "Optical coherence tomography angiography of the peripapillary retina and optic nerve head in dominant optic atrophy",

abstract = "Peripapillar and nerve head vessel density (VD) was measured in 10 patients affected by Dominant optic atrophy (DOA) using optical coherence tomography angiography (OCT-A) and compared to the measurements of 15 age- and gender-matched controls. DOA patients showed VD reduction, mostly in the temporal and inferotemporal peripapillary sectors, according to the preferential involvement of the papillomacular bundle. Despite poor best-corrected visual acuity (BCVA), OCT-A revealed good repeatability. VD correlated with functional (mean deviation of visual field and BCVA) and structural (retinal nerve fiber layer thickness) parameters and could be a non-invasive, quantitative tool for the monitoring of the disease and of the therapeutic approaches. Copyright {\^A}{\textcopyright} 2017 Elsevier B.V. and Mitochondria Research Society. All rights reserved.",

author = "Nicole Balducci and Ciardella, {Antonio P.} and R Gattegna and Q Zhou and Cascavilla, {Maria Lucia} and {La Morgia}, C and G Savini and V Parisi and F Bandello and V Carelli and Piero Barboni",

year = "2017",

doi = "10.1016/j.mito.2017.03.002",

language = "English",

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T1 - Optical coherence tomography angiography of the peripapillary retina and optic nerve head in dominant optic atrophy

AU - Balducci, Nicole

AU - Ciardella, Antonio P.

AU - Gattegna, R

AU - Zhou, Q

AU - Cascavilla, Maria Lucia

AU - La Morgia, C

AU - Savini, G

AU - Parisi, V

AU - Bandello, F

AU - Carelli, V

AU - Barboni, Piero

PY - 2017

Y1 - 2017

N2 - Peripapillar and nerve head vessel density (VD) was measured in 10 patients affected by Dominant optic atrophy (DOA) using optical coherence tomography angiography (OCT-A) and compared to the measurements of 15 age- and gender-matched controls. DOA patients showed VD reduction, mostly in the temporal and inferotemporal peripapillary sectors, according to the preferential involvement of the papillomacular bundle. Despite poor best-corrected visual acuity (BCVA), OCT-A revealed good repeatability. VD correlated with functional (mean deviation of visual field and BCVA) and structural (retinal nerve fiber layer thickness) parameters and could be a non-invasive, quantitative tool for the monitoring of the disease and of the therapeutic approaches. Copyright Â© 2017 Elsevier B.V. and Mitochondria Research Society. All rights reserved.

AB - Peripapillar and nerve head vessel density (VD) was measured in 10 patients affected by Dominant optic atrophy (DOA) using optical coherence tomography angiography (OCT-A) and compared to the measurements of 15 age- and gender-matched controls. DOA patients showed VD reduction, mostly in the temporal and inferotemporal peripapillary sectors, according to the preferential involvement of the papillomacular bundle. Despite poor best-corrected visual acuity (BCVA), OCT-A revealed good repeatability. VD correlated with functional (mean deviation of visual field and BCVA) and structural (retinal nerve fiber layer thickness) parameters and could be a non-invasive, quantitative tool for the monitoring of the disease and of the therapeutic approaches. Copyright Â© 2017 Elsevier B.V. and Mitochondria Research Society. All rights reserved.

U2 - 10.1016/j.mito.2017.03.002

DO - 10.1016/j.mito.2017.03.002

M3 - Article

VL - 36

SP - 60

EP - 65

JO - Mitochondrion

JF - Mitochondrion

SN - 1567-7249

IS - 5

ER -

Optical coherence tomography angiography of the peripapillary retina and optic nerve head in dominant optic atrophy

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