TY - JOUR
T1 - Optical coherence tomography angiography of the peripapillary retina and optic nerve head in dominant optic atrophy
AU - Balducci, Nicole
AU - Ciardella, Antonio P.
AU - Gattegna, R
AU - Zhou, Q
AU - Cascavilla, Maria Lucia
AU - La Morgia, C
AU - Savini, G
AU - Parisi, V
AU - Bandello, F
AU - Carelli, V
AU - Barboni, Piero
PY - 2017
Y1 - 2017
N2 - Peripapillar and nerve head vessel density (VD) was measured in 10 patients affected by Dominant optic atrophy (DOA) using optical coherence tomography angiography (OCT-A) and compared to the measurements of 15 age- and gender-matched controls. DOA patients showed VD reduction, mostly in the temporal and inferotemporal peripapillary sectors, according to the preferential involvement of the papillomacular bundle. Despite poor best-corrected visual acuity (BCVA), OCT-A revealed good repeatability. VD correlated with functional (mean deviation of visual field and BCVA) and structural (retinal nerve fiber layer thickness) parameters and could be a non-invasive, quantitative tool for the monitoring of the disease and of the therapeutic approaches. Copyright © 2017 Elsevier B.V. and Mitochondria Research Society. All rights reserved.
AB - Peripapillar and nerve head vessel density (VD) was measured in 10 patients affected by Dominant optic atrophy (DOA) using optical coherence tomography angiography (OCT-A) and compared to the measurements of 15 age- and gender-matched controls. DOA patients showed VD reduction, mostly in the temporal and inferotemporal peripapillary sectors, according to the preferential involvement of the papillomacular bundle. Despite poor best-corrected visual acuity (BCVA), OCT-A revealed good repeatability. VD correlated with functional (mean deviation of visual field and BCVA) and structural (retinal nerve fiber layer thickness) parameters and could be a non-invasive, quantitative tool for the monitoring of the disease and of the therapeutic approaches. Copyright © 2017 Elsevier B.V. and Mitochondria Research Society. All rights reserved.
U2 - 10.1016/j.mito.2017.03.002
DO - 10.1016/j.mito.2017.03.002
M3 - Article
VL - 36
SP - 60
EP - 65
JO - Mitochondrion
JF - Mitochondrion
SN - 1567-7249
IS - 5
ER -