Optical coherence tomography angiography of the peripapillary retina and optic nerve head in dominant optic atrophy

Nicole Balducci, Antonio P. Ciardella, R Gattegna, Q Zhou, Maria Lucia Cascavilla, C La Morgia, G Savini, V Parisi, F Bandello, V Carelli, Piero Barboni

Research output: Contribution to journalArticle

Abstract

Peripapillar and nerve head vessel density (VD) was measured in 10 patients affected by Dominant optic atrophy (DOA) using optical coherence tomography angiography (OCT-A) and compared to the measurements of 15 age- and gender-matched controls. DOA patients showed VD reduction, mostly in the temporal and inferotemporal peripapillary sectors, according to the preferential involvement of the papillomacular bundle. Despite poor best-corrected visual acuity (BCVA), OCT-A revealed good repeatability. VD correlated with functional (mean deviation of visual field and BCVA) and structural (retinal nerve fiber layer thickness) parameters and could be a non-invasive, quantitative tool for the monitoring of the disease and of the therapeutic approaches. Copyright © 2017 Elsevier B.V. and Mitochondria Research Society. All rights reserved.
Original languageEnglish
Pages (from-to)60-65
Number of pages6
JournalMitochondrion
Volume36
Issue number5
DOIs
Publication statusPublished - 2017

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