Optical coherence tomography in Alzheimer's disease: A meta-analysis

Gianluca Coppola, Antonio Di Renzo, Lucia Ziccardi, Francesco Martelli, Antonello Fadda, Gianluca Manni, Piero Barboni, Francesco Pierelli, Alfredo A. Sadun, Vincenzo Parisi

Research output: Contribution to journalArticlepeer-review


Background: Alzheimer's disease (AD) is a neurodegenerative disorder, which is likely to start as mild cognitive impairment (MCI) several years before the its full-blown clinical manifestation. Optical coherence tomography (OCT) has been used to detect a loss in peripapillary retina nerve fiber layer (RNFL) and a reduction in macular thickness and volume of people affected by MCI or AD. Here, we performed an aggregate meta-analysis combining results from different studies. Methods and Findings: Data sources were case-control studies published between January 2001 and August 2014 (identified through PubMed and Google Scholar databases) that examined the RNFL thickness by means of OCT in AD and MCI patients compared with cognitively healthy controls. Results: 11 studies were identified, including 380 patients with AD, 68 with MCI and 293 healthy controls (HC). The studies suggest that the mean RNFL thickness is reduced in MCI (weighted mean differences in μm, WMD = -13.39, 95% CI: -17.34 to -9.45, p = 0.031) and, even more so, in AD (WMD = -15.95, 95% CI: -21.65 to -10.21, p

Original languageEnglish
Article numbere0134750
JournalPLoS One
Issue number8
Publication statusPublished - Aug 7 2015

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)


Dive into the research topics of 'Optical coherence tomography in Alzheimer's disease: A meta-analysis'. Together they form a unique fingerprint.

Cite this