Optical coherence tomography in Alzheimer's disease: A meta-analysis

Gianluca Coppola; Antonio Di Renzo; Lucia Ziccardi; Francesco Martelli; Antonello Fadda; Gianluca Manni; Piero Barboni; Francesco Pierelli; Alfredo A. Sadun; Vincenzo Parisi

doi:10.1371/journal.pone.0134750

Optical coherence tomography in Alzheimer's disease: A meta-analysis

Gianluca Coppola, Antonio Di Renzo, Lucia Ziccardi, Francesco Martelli, Antonello Fadda, Gianluca Manni, Piero Barboni, Francesco Pierelli, Alfredo A. Sadun, Vincenzo Parisi

Research output: Contribution to journal › Article

Abstract

Background: Alzheimer's disease (AD) is a neurodegenerative disorder, which is likely to start as mild cognitive impairment (MCI) several years before the its full-blown clinical manifestation. Optical coherence tomography (OCT) has been used to detect a loss in peripapillary retina nerve fiber layer (RNFL) and a reduction in macular thickness and volume of people affected by MCI or AD. Here, we performed an aggregate meta-analysis combining results from different studies. Methods and Findings: Data sources were case-control studies published between January 2001 and August 2014 (identified through PubMed and Google Scholar databases) that examined the RNFL thickness by means of OCT in AD and MCI patients compared with cognitively healthy controls. Results: 11 studies were identified, including 380 patients with AD, 68 with MCI and 293 healthy controls (HC). The studies suggest that the mean RNFL thickness is reduced in MCI (weighted mean differences in μm, WMD = -13.39, 95% CI: -17.34 to -9.45, p = 0.031) and, even more so, in AD (WMD = -15.95, 95% CI: -21.65 to -10.21, p

Original language	English
Article number	e0134750
Journal	PLoS One
Volume	10
Issue number	8
DOIs	https://doi.org/10.1371/journal.pone.0134750
Publication status	Published - Aug 7 2015

ASJC Scopus subject areas

Agricultural and Biological Sciences(all)
Biochemistry, Genetics and Molecular Biology(all)
Medicine(all)

Access to Document

10.1371/journal.pone.0134750

Fingerprint Dive into the research topics of 'Optical coherence tomography in Alzheimer's disease: A meta-analysis'. Together they form a unique fingerprint.

Cite this

Coppola, G., Di Renzo, A., Ziccardi, L., Martelli, F., Fadda, A., Manni, G., Barboni, P., Pierelli, F., Sadun, A. A., & Parisi, V. (2015). Optical coherence tomography in Alzheimer's disease: A meta-analysis. PLoS One, 10(8), [e0134750]. https://doi.org/10.1371/journal.pone.0134750

@article{3f6e0a66358c4ed9a730541e8497e241,

title = "Optical coherence tomography in Alzheimer's disease: A meta-analysis",

abstract = "Background: Alzheimer's disease (AD) is a neurodegenerative disorder, which is likely to start as mild cognitive impairment (MCI) several years before the its full-blown clinical manifestation. Optical coherence tomography (OCT) has been used to detect a loss in peripapillary retina nerve fiber layer (RNFL) and a reduction in macular thickness and volume of people affected by MCI or AD. Here, we performed an aggregate meta-analysis combining results from different studies. Methods and Findings: Data sources were case-control studies published between January 2001 and August 2014 (identified through PubMed and Google Scholar databases) that examined the RNFL thickness by means of OCT in AD and MCI patients compared with cognitively healthy controls. Results: 11 studies were identified, including 380 patients with AD, 68 with MCI and 293 healthy controls (HC). The studies suggest that the mean RNFL thickness is reduced in MCI (weighted mean differences in μm, WMD = -13.39, 95% CI: -17.34 to -9.45, p = 0.031) and, even more so, in AD (WMD = -15.95, 95% CI: -21.65 to -10.21, p",

author = "Gianluca Coppola and {Di Renzo}, Antonio and Lucia Ziccardi and Francesco Martelli and Antonello Fadda and Gianluca Manni and Piero Barboni and Francesco Pierelli and Sadun, {Alfredo A.} and Vincenzo Parisi",

year = "2015",

month = aug,

day = "7",

doi = "10.1371/journal.pone.0134750",

language = "English",

volume = "10",

journal = "PLoS One",

issn = "1932-6203",

publisher = "Public Library of Science",

number = "8",

}

TY - JOUR

T1 - Optical coherence tomography in Alzheimer's disease

T2 - A meta-analysis

AU - Coppola, Gianluca

AU - Di Renzo, Antonio

AU - Ziccardi, Lucia

AU - Martelli, Francesco

AU - Fadda, Antonello

AU - Manni, Gianluca

AU - Barboni, Piero

AU - Pierelli, Francesco

AU - Sadun, Alfredo A.

AU - Parisi, Vincenzo

PY - 2015/8/7

Y1 - 2015/8/7

N2 - Background: Alzheimer's disease (AD) is a neurodegenerative disorder, which is likely to start as mild cognitive impairment (MCI) several years before the its full-blown clinical manifestation. Optical coherence tomography (OCT) has been used to detect a loss in peripapillary retina nerve fiber layer (RNFL) and a reduction in macular thickness and volume of people affected by MCI or AD. Here, we performed an aggregate meta-analysis combining results from different studies. Methods and Findings: Data sources were case-control studies published between January 2001 and August 2014 (identified through PubMed and Google Scholar databases) that examined the RNFL thickness by means of OCT in AD and MCI patients compared with cognitively healthy controls. Results: 11 studies were identified, including 380 patients with AD, 68 with MCI and 293 healthy controls (HC). The studies suggest that the mean RNFL thickness is reduced in MCI (weighted mean differences in μm, WMD = -13.39, 95% CI: -17.34 to -9.45, p = 0.031) and, even more so, in AD (WMD = -15.95, 95% CI: -21.65 to -10.21, p

AB - Background: Alzheimer's disease (AD) is a neurodegenerative disorder, which is likely to start as mild cognitive impairment (MCI) several years before the its full-blown clinical manifestation. Optical coherence tomography (OCT) has been used to detect a loss in peripapillary retina nerve fiber layer (RNFL) and a reduction in macular thickness and volume of people affected by MCI or AD. Here, we performed an aggregate meta-analysis combining results from different studies. Methods and Findings: Data sources were case-control studies published between January 2001 and August 2014 (identified through PubMed and Google Scholar databases) that examined the RNFL thickness by means of OCT in AD and MCI patients compared with cognitively healthy controls. Results: 11 studies were identified, including 380 patients with AD, 68 with MCI and 293 healthy controls (HC). The studies suggest that the mean RNFL thickness is reduced in MCI (weighted mean differences in μm, WMD = -13.39, 95% CI: -17.34 to -9.45, p = 0.031) and, even more so, in AD (WMD = -15.95, 95% CI: -21.65 to -10.21, p

UR - http://www.scopus.com/inward/record.url?scp=84941955657&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84941955657&partnerID=8YFLogxK

U2 - 10.1371/journal.pone.0134750

DO - 10.1371/journal.pone.0134750

M3 - Article

AN - SCOPUS:84941955657

VL - 10

JO - PLoS One

JF - PLoS One

SN - 1932-6203

IS - 8

M1 - e0134750

ER -