Optical coherence tomography (OCT) in retinal angiomatous proliferation (RAP)

R. Brancato, U. Introini, L. Pierro, M. Setaccioli, M. Forti, G. Bolognesi, G. Tremolada

Research output: Contribution to journalArticlepeer-review


PURPOSE. To verify the utility of optical coherence tomography (OCT) for diagnosing retinal angiomatous proliferations (RAP) in patients with exudative age-related macular degeneration (AMD). METHODS. Multiple cross-sections were taken with OCT from 41 eyes of 39 consecutive patients with AMD and RAP. The presence and the location of the angiomatous cyomplexes had already been documented by fluorescein angiography (FA) and high-speed confocal indocyanine green videoangiography (ICGA). RESULTS. RAP was detectable by OCT scans in all 41 eyes, appearing as a focal hyper-reflecting area in the neuroretinal layers; it was frequently located close to the inner surface of the retinal pigment epithelium (29 eyes [70.7%]). All eyes had either no or only a low-reflecting OCT signal surrounding the RAP, caused by serous intraretinal edema. Only 13 eyes (31.7%), however, had large serous retinal detachment (SRD). OCT detected pigment epithelium detachment in 31 eyes (75.6%), but none had underlying choroidal neovascularization. CONCLUSIONS. OCT findings confirm the intraretinal localization of the RAP which are always associated with impressive exudative phenomena. OCT is therefore a useful diagnostic tool, adding information to FA and high-speed ICGA.

Original languageEnglish
Pages (from-to)467-472
Number of pages6
JournalEuropean Journal of Ophthalmology
Issue number6
Publication statusPublished - Nov 2002


  • Age-related macular degeneration (AMD)
  • Choroidal neovascularization
  • Indocyanine green angiography (ICGA)
  • Optical coherence tomography (OCT)
  • Retinal angiomatous proliferation (RAP)
  • Serous retinal detachment (SRD)

ASJC Scopus subject areas

  • Ophthalmology


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