Optical imaging of alpha emitters: Simulations, phantom,and in vivo results

Federico Boschi, Sergio Lo Meo, Pier Luca Rossi, Riccardo Calandrino, Andrea Sbarbati, Antonello E. Spinelli

Research output: Contribution to journalArticlepeer-review

Abstract

There has been growing interest in investigating both the in vitro and in vivo detection of optical photons from a plethora of beta emitters using optical techniques. In this paper we have investigated an alpha particle induced fluorescence signal by using a commercial CCD-based small animal optical imaging system. The light emission of a 241 Am source was simulated using GEANT4 and tested in different experimental conditions including the imaging of in vivo tissue. We believe that the results Dresented in this work can be useful to describe a possible mechanism tor the in vivo detection ot alpha emitters used tor therapeutic purposes.

Original languageEnglish
Article number126011
JournalJournal of Biomedical Optics
Volume16
Issue number12
DOIs
Publication statusPublished - Dec 2011

Keywords

  • Biology
  • Biomedical optics
  • Fluorescence
  • Medicine

ASJC Scopus subject areas

  • Biomedical Engineering
  • Biomaterials
  • Electronic, Optical and Magnetic Materials
  • Atomic and Molecular Physics, and Optics

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