Optical imaging of radioisotopes: A novel multimodal approach to molecular imaging

A. E. Spinelli, M. Marengo, R. Calandrino, A. Sbarbati, F. Boschi

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

In this review there will be presented an overview of the literature about the recent developments on radiotracers imaging using optical methods and their applications. We will begin with a short summary regarding the discovery of Cerenkov radiation (CR) and then focus on the early developments and experimental validation of planar Cerenkov luminescence imaging. A significant improvement in Cerenkov luminescence imaging was given by the development of tomographic methods in order to obtain in vivo whole body 3D images of Cerenkov sources. An interesting and original application discussed in this review is the use of CR as the excitation source of quantum dots and fluorophores. We will also present some recent experimental results on in vivo radio luminescence imaging of alpha and gamma emitters. All these results make optical radioisotopes imaging an interesting cost-effective tool for the screening of new probes for both imaging and therapeutic applications. Other interesting aspects are the uses of Cerenkov radiation for radiotherapy and for radiopharmaceuticals synthesis applications. We will conclude by summarising the most important results and the future challenges.

Original languageEnglish
Pages (from-to)280-290
Number of pages11
JournalQuarterly Journal of Nuclear Medicine and Molecular Imaging
Volume56
Issue number3
Publication statusPublished - Jun 2012

Fingerprint

Molecular Imaging
Optical Imaging
Luminescence
Radioisotopes
Radiation
Quantum Dots
Radiopharmaceuticals
Body Image
Radio
Radiotherapy
Costs and Cost Analysis
Therapeutics

Keywords

  • Electromagnetic radiation
  • Molecular imaging
  • Radiopharmaceuticals

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Cite this

Optical imaging of radioisotopes : A novel multimodal approach to molecular imaging. / Spinelli, A. E.; Marengo, M.; Calandrino, R.; Sbarbati, A.; Boschi, F.

In: Quarterly Journal of Nuclear Medicine and Molecular Imaging, Vol. 56, No. 3, 06.2012, p. 280-290.

Research output: Contribution to journalArticle

@article{05969c893b0a4cab9050610dd9193cab,
title = "Optical imaging of radioisotopes: A novel multimodal approach to molecular imaging",
abstract = "In this review there will be presented an overview of the literature about the recent developments on radiotracers imaging using optical methods and their applications. We will begin with a short summary regarding the discovery of Cerenkov radiation (CR) and then focus on the early developments and experimental validation of planar Cerenkov luminescence imaging. A significant improvement in Cerenkov luminescence imaging was given by the development of tomographic methods in order to obtain in vivo whole body 3D images of Cerenkov sources. An interesting and original application discussed in this review is the use of CR as the excitation source of quantum dots and fluorophores. We will also present some recent experimental results on in vivo radio luminescence imaging of alpha and gamma emitters. All these results make optical radioisotopes imaging an interesting cost-effective tool for the screening of new probes for both imaging and therapeutic applications. Other interesting aspects are the uses of Cerenkov radiation for radiotherapy and for radiopharmaceuticals synthesis applications. We will conclude by summarising the most important results and the future challenges.",
keywords = "Electromagnetic radiation, Molecular imaging, Radiopharmaceuticals",
author = "Spinelli, {A. E.} and M. Marengo and R. Calandrino and A. Sbarbati and F. Boschi",
year = "2012",
month = "6",
language = "English",
volume = "56",
pages = "280--290",
journal = "Quarterly Journal of Nuclear Medicine and Molecular Imaging",
issn = "1824-4785",
publisher = "Edizioni Minerva Medica S.p.A.",
number = "3",

}

TY - JOUR

T1 - Optical imaging of radioisotopes

T2 - A novel multimodal approach to molecular imaging

AU - Spinelli, A. E.

AU - Marengo, M.

AU - Calandrino, R.

AU - Sbarbati, A.

AU - Boschi, F.

PY - 2012/6

Y1 - 2012/6

N2 - In this review there will be presented an overview of the literature about the recent developments on radiotracers imaging using optical methods and their applications. We will begin with a short summary regarding the discovery of Cerenkov radiation (CR) and then focus on the early developments and experimental validation of planar Cerenkov luminescence imaging. A significant improvement in Cerenkov luminescence imaging was given by the development of tomographic methods in order to obtain in vivo whole body 3D images of Cerenkov sources. An interesting and original application discussed in this review is the use of CR as the excitation source of quantum dots and fluorophores. We will also present some recent experimental results on in vivo radio luminescence imaging of alpha and gamma emitters. All these results make optical radioisotopes imaging an interesting cost-effective tool for the screening of new probes for both imaging and therapeutic applications. Other interesting aspects are the uses of Cerenkov radiation for radiotherapy and for radiopharmaceuticals synthesis applications. We will conclude by summarising the most important results and the future challenges.

AB - In this review there will be presented an overview of the literature about the recent developments on radiotracers imaging using optical methods and their applications. We will begin with a short summary regarding the discovery of Cerenkov radiation (CR) and then focus on the early developments and experimental validation of planar Cerenkov luminescence imaging. A significant improvement in Cerenkov luminescence imaging was given by the development of tomographic methods in order to obtain in vivo whole body 3D images of Cerenkov sources. An interesting and original application discussed in this review is the use of CR as the excitation source of quantum dots and fluorophores. We will also present some recent experimental results on in vivo radio luminescence imaging of alpha and gamma emitters. All these results make optical radioisotopes imaging an interesting cost-effective tool for the screening of new probes for both imaging and therapeutic applications. Other interesting aspects are the uses of Cerenkov radiation for radiotherapy and for radiopharmaceuticals synthesis applications. We will conclude by summarising the most important results and the future challenges.

KW - Electromagnetic radiation

KW - Molecular imaging

KW - Radiopharmaceuticals

UR - http://www.scopus.com/inward/record.url?scp=84865316514&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84865316514&partnerID=8YFLogxK

M3 - Article

C2 - 22695338

AN - SCOPUS:84865316514

VL - 56

SP - 280

EP - 290

JO - Quarterly Journal of Nuclear Medicine and Molecular Imaging

JF - Quarterly Journal of Nuclear Medicine and Molecular Imaging

SN - 1824-4785

IS - 3

ER -