Optical mammography: A new technique for visualizing breast lesions in women presenting non palpable BIRADS 4-5 imaging findings: Preliminary results with radiologic-pathologic correlation

Alexandra Athanasiou, Daniel Vanel, Laure Fournier, Corinne Balleyguier

Research output: Contribution to journalArticle

Abstract

The purpose of this prospective study is to determine the diagnostic accuracy of near-infrared breast optical absorption imaging in patients with Breast Imaging Reporting and Data System (BIRADS) 4-5 non-palpable lesions scheduled for biopsy, using pathology after core or excisional biopsy as a reference. The patient's breast was positioned onto a panel of red light-emitting diodes (640nm). A soft membrane was inflated to exert a uniform pressure on the breast. Transmitted light was detected using a CCD camera. The entire acquisition sequence took 1 minute. Image processing generated dynamic images displayed in colour scale, to reveal time-dependent changes in the transmitted light intensity caused by the pressure change. Dynamic curves were classified in two categories: consistently decreasing intensity suspicious for malignancy, and sinusoidal increasing intensity considered as benign. Seventy-eight women consulting for non-palpable breast lesions were initially included in the study. An imaging - histology correlation was obtained for seventy-two patients, the remaining six patients were excluded for technical optical scan reasons. We experienced an overall sensitivity of 73% and specificity of 38%, the false negative results being mainly small size (

Original languageEnglish
Pages (from-to)34-40
Number of pages7
JournalCancer Imaging
Volume7
Issue number1
DOIs
Publication statusPublished - 2007

Keywords

  • Breast
  • Near-infrared optical absorption imaging

ASJC Scopus subject areas

  • Medicine(all)
  • Oncology
  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology

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